Glucocorticoid receptor (GR) activation has been shown to reduce adult hippocampal
progenitor cell proliferation and neurogenesis. By contrast, mineralocorticoid receptor (MR) …

High level of serum corticosteroid is frequently associated with depression, in which a
notable HPA (hypothalamus-pituitary-adrenal) axis hyperactivity is often observed. There …

Increased glucocorticoids (GCs) have been implicated in the pathophysiology of depressive
disorder. We previously found that dexamethasone (DEX, a synthetic GC) repressed brain …

An abnormality in adaptation to negative life events is considered as one of the main causes
of the development of depressive symptoms. According to the corticosteroid receptor …

Chronic stress is a risk factor for several neuropsychiatric diseases, such as depression and
psychosis. In response to stress glucocorticoids (GCs) are secreted that bind to …

The Glucocorticoid Receptor (GR) is a transcription factor ubiquitously expressed in the
brain. Activation of brain GRs by high levels of glucocorticoid (GC) hormones modifies a …

The ability of an organism to adapt during stress has a significant impact on long-term
survival and health. Maladaptive responses to stress have been associated with …

Chronic psychological stress is one of the most important triggers and environmental risk
factors for neuropsychiatric disorders. Chronic stress can influence all organs via the …

Abnormal glucocorticoid and neurotrophin signaling has been implicated in numerous
psychiatric disorders. However, the impact of neurotrophic signaling on glucocorticoid …

Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to
injury or disease. In the brain, stress/GCs can alter neuron structure and function leading to …