A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive
impairment. However, the mechanisms involved in this age-related reduction remain …

The brain-derived neurotrophic factor (BDNF) is a key player in brain functions such as
synaptic plasticity, stress, and behavior. Its gene structure in rodents contains 8 untranslated …

Stress is a major risk factor for depression and anxiety. One of the effects of stress is the
(over-) activation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of stress …

Corticosteroids (CSs) are widely used clinically, for example in pediatric respiratory distress
syndrome, and immunosuppression to prevent rejection of stem cell transplant populations …

Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis is associated with
vulnerability to a number of psychiatric diseases including major depression, bipolar …

Major depression is thought to originate from maladaptation to adverse events, particularly
when impairments occur in mood-related brain regions. Hypothalamus–pituitary–adrenal …

Glucocorticoids serve as key stress response hormones that facilitate stress coping.
However, sustained glucocorticoid exposure is associated with adverse consequences on …

Recent research suggests an involvement of hippocampal neurogenesis in behavioral
effects of antidepressants. However, the precise mechanisms through which newborn …

Glucocorticoids (GCs) secreted after stress reduce adult hippocampal neurogenesis, a
process that has been implicated in cognitive aspects of psychopathology, amongst others …

The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external
stressors. Many patients diagnosed with conditions such as depression or anxiety also have …