Background: Glucocorticoid (GC) receptor (GR) signaling in the hypothalamus (Hyp) and in
the superordinate limbic structures, such as the hippocampus (Hip), conveys feedback …

Previous studies have primarily interpreted gene expression regulation by glucocorticoids in
the brain in terms of impact on neurons; however, less is known about the corresponding …

Repeated stressful events are known to be associated with onset of depression. Further,
stress activates the hypothalamic–pituitary–adrenocortical (HPA) system by elevating …

Synaptic deficits and neuronal dystrophy in the prefrontal cortex (PFC) are linked to
behavioral and cognitive symptoms in depressed individuals. Preclinical studies indicate …

Neurotrophins and glucocorticoids are robust synaptic modifiers, and deregulation of their
activities is a risk factor for developing stress-related disorders. Low levels of brain-derived …

Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis is one of the most consistent
findings in major depressive disorder (MDD). Impaired HPA feedback may be due to the …

A comprehensive overview of the interplay between glucocorticoids (GCs) and adult
hippocampal neurogenesis (AHN) is presented, particularly, in the context of a diseased …

Corticosteroids can influence brain function, and glucocorticoid hormone receptors (GRs)
are present in brain tissue. We observed that GR and also mineralocorticoid receptor (MR) …

The glucocorticoid receptor (GR) is critically involved in regulation of stress responses
[inhibition of the hypothalamic-pituitary-adrenal (HPA) axis], emotional behavior and …

Adult hippocampal neurogenesis is decreased in rodent models for stress-related disorders
partly through an elevated level of glucocorticoids (GCs). On the other hand, lithium (Li), a …