Pathologic TAR-DNA-binding protein 43 (TDP-43) is a disease protein in frontotemporal
lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral …

Rapid advances were made in the knowledge of amyotrophic lateral sclerosis (ALS) with the
recent identification of TARDBP and FUS mutations in familial ALS. More recently, FUS …

Trans-activation response DNA-binding protein (TDP-43) accumulation is the major
component of ubiquitinated protein inclusions found in patients with amyotrophic lateral …

A nuclear protein, 43-kDa TAR DNA-binding protein (TDP-43), was recently identified as a
component of the ubiquitinated inclusions (UIs) in frontotemporal lobar degeneration (FTLD …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin
positive inclusions (FTLD-U) are two clinically distinct neurodegenerative conditions sharing …

The abnormal assembly of TAR DNA-binding protein 43 (TDP-43) in neuronal and glial cells
characterizes nearly all cases of amyotrophic lateral sclerosis (ALS) and around half of …

Accumulations of aggregated proteins are a key feature of the pathology of all of the major
neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) was brought into this fold …

Over the last two decades many secrets of the age-related human neural proteinopathies
have been revealed. A common feature of these diseases is abnormal, and possibly …

TAR DNA-binding protein (TDP-43) has been recently described as a major pathological
protein in both frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and …

Abstract TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated
inclusions in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype …