Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls

Z Majkova, J Layne, M Sunkara, AJ Morris… - Toxicology and applied …, 2011 - Elsevier
Coplanar polychlorinated biphenyls (PCBs) may facilitate development of atherosclerosis by
stimulating pro-inflammatory pathways in the vascular endothelium. Nutrition, including fish …

Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells

L Wang, G Reiterer, M Toborek, B Hennig - Chemico-biological interactions, 2008 - Elsevier
Exposure to persistent organic pollutants, such as polychlorinated biphenyls (PCBs) can
cause endothelial cell (EC) activation by inducing pro-inflammatory signaling pathways. Our …

Linoleic acid amplifies polychlorinated biphenyl‐mediated dysfunction of endothelial cells

B Hennig, R Slim, M Toborek… - Journal of biochemical …, 1999 - Wiley Online Library
Selected dietary lipids may increase the atherogenicity of environmental chemicals, such as
polychlorinated biphenyls (PCBs), by cross‐amplifying mechanisms leading to dysfunction …

Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence

B Hennig, P Meerarani, R Slim, M Toborek… - Toxicology and applied …, 2002 - Elsevier
So-called coplanar polychlorinated biphenyls (PCBs), as well as other environmental
contaminants that are aryl hydrocarbon receptor (AhR) agonists, may compromise the …

The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells

R Slim, BD Hammock, M Toborek… - Toxicology and applied …, 2001 - Elsevier
Selected dietary lipids may increase the atherogenic effects of environmental chemicals,
such as polychlorinated biphenyls (PCBs), by cross-amplifying mechanisms leading to …

Polychlorinated biphenyl quinone promotes atherosclerosis through lipid accumulation and endoplasmic reticulum stress via CD36

B Yang, Q Qin, L Xu, X Lv, Z Liu, E Song… - Chemical Research in …, 2020 - ACS Publications
Polychlorinated biphenyls (PCBs) are persistent organic environmental pollutants.
According to previous epidemiological reports, PCBs exposure is highly related to …

Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells

P Ramadass, P Meerarani, M Toborek… - Toxicological …, 2003 - academic.oup.com
Polychlorinated biphenyls (PCBs), especially the more coplanar PCBs, have been shown to
induce oxidative stress, various transcription factors, and subsequent inflammatory …

PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis

W Choi, SY Eum, YW Lee, B Hennig… - Toxicological …, 2003 - academic.oup.com
Polychlorinated biphenyls (PCBs) are widespread environmental contaminants that are
known to induce carcinogenic and possibly atherogenic events. Recent evidence suggests …

PCB 118-induced endothelial cell apoptosis is partially mediated by excessive ROS production

L Tang, J Cheng, Y Long, X He, G Liang… - Toxicology …, 2017 - Taylor & Francis
Endothelial cell apoptosis, which may alter the integrity of the endothelium and lead to
plaque instability, plays a critical role in the development and pathogenesis of …

Dietary omega-3 polyunsaturated fatty acids prevent vascular dysfunction and attenuate cytochrome P4501A1 expression by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin

EF Wiest, MT Walsh-Wilcox, M Rothe… - Toxicological …, 2016 - academic.oup.com
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) found in fish protect against
cardiovascular morbidity and mortality; however, many individuals avoid fish consumption …