Multi-omics analysis of cancer cell lines with high/low ferroptosis scores and development of a ferroptosis-related model for multiple cancer types

G Shan, H Zhang, G Bi, Y Bian, J Liang… - Frontiers in cell and …, 2021 - frontiersin.org
Background: Ferroptosis is a newly identified regulated cell death characterized by iron-
dependent lipid peroxidation and subsequent membrane oxidative damage, which has …

Systematic analysis of the aberrances and functional implications of ferroptosis in cancer

Z Liu, Q Zhao, ZX Zuo, SQ Yuan, K Yu, Q Zhang… - Iscience, 2020 - cell.com
Ferroptosis is a type of cell death related to cancer; however, the characteristics of
ferroptosis in cancers are still uncertain. Based on the data in The Cancer Genome Atlas, we …

A novel ferroptosis-related genes model for prognosis prediction of lung adenocarcinoma

F Li, D Ge, S Sun - BMC Pulmonary Medicine, 2021 - Springer
Background Ferroptosis is a newly discovered form of cell death characterized by iron-
dependent lipid peroxidation. This study aims to investigate the potential correlation …

[HTML][HTML] Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types

B Tang, R Yan, J Zhu, S Cheng, C Kong… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a recently described mode of cell death caused by the accumulation of
intracellular iron and lipid reactive oxygen species (ROS), which play critical roles in …

Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma

G Tu, W Peng, Q Cai, Z Zhao, X Peng, B He, P Zhang… - PeerJ, 2021 - peerj.com
Background Ferroptosis is a novel form of programmed cell death characterized by the
excessive accumulation of intracellular iron and an increase in reactive oxygen species …

Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

Y Vinik, A Maimon, V Dubey, H Raj… - Advanced …, 2024 - Wiley Online Library
Ferroptosis and apoptosis are key cell‐death pathways implicated in several human
diseases including cancer. Ferroptosis is driven by iron‐dependent lipid peroxidation and …

Prognostic role and potential mechanisms of the ferroptosis-related metabolic gene signature in hepatocellular carcinoma

T Dai, J Li, X Lu, L Ye, H Yu, L Zhang… - Pharmacogenomics …, 2021 - Taylor & Francis
Purpose Ferroptosis, as a novel regulated cell death form, has a close interaction with
metabolism, which is largely unknown in cancer. In the present study, we conducted a …

Ferroptosis characterization in lung adenocarcinomas reveals prognostic signature with immunotherapeutic implication

S Sun, Y Yang, Z Yang, J Wang, R Li, H Tian… - Frontiers in cell and …, 2021 - frontiersin.org
The iron-dependent cell death named ferroptosis has been implicated in the progression
and therapeutic response of several tumors. However, potential role of ferroptosis in lung …

Multi-omics characterization and therapeutic liability of ferroptosis in melanoma

Y He, Y Dong, Y Chen, G Zhang, H Zhang… - … and Targeted Therapy, 2022 - nature.com
Ferroptosis, an iron-dependent form of programmed cell death driven by excessive lipid
peroxidation, 1 has emerged as a promising and effective strategy for triggering cancer cell …

[HTML][HTML] Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer

K Fang, Z Xu, S Jiang, C Yan, D Tang… - Frontiers in …, 2022 - frontiersin.org
Objective Ferroptosis is an iron-dependent type of regulated cell death triggered by the toxic
buildup of lipid peroxides on cell membranes. Nonetheless, the implication of ferroptosis in …