Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

AM Brickman, JJ Manly, LS Honig… - Annals of clinical …, 2022 - Wiley Online Library
Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific
for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were …

Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines

KR Thomas, KJ Bangen, EC Edmonds… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Objectively‐defined subtle cognitive decline (Obj‐SCD) and plasma
phosphorylated‐tau181 (p‐tau181) are promising early Alzheimer's disease (AD) markers …

Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease

C Tissot, A L. Benedet, J Therriault, TA Pascoal… - Alzheimer's Research & …, 2021 - Springer
Background To investigate the association of plasma pTau181, assessed with a new
immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and …

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

J Simrén, A Leuzy, TK Karikari, A Hye… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction This study investigated the diagnostic and disease‐monitoring potential of
plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) …

Association of plasma P-tau181 with memory decline in non-demented adults

J Therriault, AL Benedet, TA Pascoal… - Brain …, 2021 - academic.oup.com
Alzheimer's disease is the leading cause of dementia worldwide and is characterized by a
long preclinical phase in which amyloid-β and tau accumulate in the absence of cognitive …

Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease

PR Kac, F Gonzalez-Ortiz, J Simrén, N Dewit… - Alzheimer's Research & …, 2022 - Springer
Background Blood phosphorylated tau (p-tau) forms are promising Alzheimer's disease (AD)
biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) …

Plasma p‐tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau

B Frank, M Ally, B Brekke, H Zetterberg… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction We examined the ability of plasma hyperphosphorylated tau (p‐tau) 181 to
detect cognitive impairment due to Alzheimer's disease (AD) independently and in …

Phospho‐specific plasma p‐tau181 assay detects clinical as well as asymptomatic Alzheimer's disease

S De Meyer, J Vanbrabant… - Annals of clinical …, 2022 - Wiley Online Library
Abstract Objective Plasma phosphorylated‐tau‐181 (p‐tau181) reliably detects clinical
Alzheimer's disease (AD) as well as asymptomatic amyloid‐β (Aβ) pathology, but is …

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

S Janelidze, N Mattsson, S Palmqvist, R Smith… - Nature medicine, 2020 - nature.com
Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer's disease (AD),
but its usefulness for differential diagnosis and prognosis is unclear. We studied plasma P …

Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects

JB Pereira, S Janelidze, E Stomrud, S Palmqvist… - Brain, 2021 - academic.oup.com
It is currently unclear whether plasma biomarkers can be used as independent prognostic
tools to predict changes associated with early Alzheimer's disease. In this study, we sought …