Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment

S Janelidze, NR Barthélemy, G Salvadó… - JAMA …, 2024 - jamanetwork.com
Importance Phase 3 trials of successful antiamyloid therapies in Alzheimer disease (AD)
have demonstrated improved clinical efficacy in people with less severe disease. Plasma …

Predictive blood biomarkers and brain changes associated with age-related cognitive decline

TS Saunders, FE Pozzolo, A Heslegrave… - Brain …, 2023 - academic.oup.com
Growing evidence supports the use of plasma levels of tau phosphorylated at threonine 181,
amyloid-β, neurofilament light and glial fibrillary acidic protein as promising biomarkers for …

[HTML][HTML] Diagnostic and prognostic performance to detect Alzheimer's disease and clinical progression of a novel assay for plasma p-tau217

C Groot, C Cicognola, D Bali, G Triana-Baltzer… - Alzheimer's research & …, 2022 - Springer
Background Recent advances in disease-modifying treatments highlight the need for
accurately identifying individuals in early Alzheimer's disease (AD) stages and for …

[HTML][HTML] The potential impact of clinical factors on blood-based biomarkers for Alzheimer's disease

F Pan, Y Lu, Q Huang, F Xie, J Yang, Q Guo - Translational …, 2023 - Springer
With the development of testing technologies, bloodbased biomarkers for Alzheimer's
disease (AD) such as amyloid-β (Aβ), phosphorylated tau (P-tau), and neurofilament light …

[HTML][HTML] Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort

AJ Mendes, F Ribaldi, A Lathuiliere, NJ Ashton… - Journal of …, 2024 - Springer
Background and objective Phosphorylated tau (p-tau) 217 has recently received attention
because it seems more reliable than other p-tau variants for identifying Alzheimer's disease …

Fully automated measurement of plasma Aβ42/40 and p‐tau181: Analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease …

G Bellomo, S Bayoumy, A Megaro, A Toja… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION For routine clinical implementation of Alzheimer's disease (AD) plasma
biomarkers, fully automated random‐access platforms are crucial to ensure reproducible …

Plasma Aβ42/Aβ40 and p-tau181 predict long-term clinical progression in a cohort with amnestic mild cognitive impairment

Z Xiao, W Wu, X Ma, X Liang, J Lu, L Zheng… - Clinical …, 2022 - academic.oup.com
Background Previous studies reported the value of blood-based biomarkers in predicting
Alzheimer disease (AD) progression among individuals with different disease stages …

Does CSF p-tau181 help to discriminate Alzheimer's disease from other dementias and mild cognitive impairment? A meta-analysis of the literature

W Tang, Q Huang, YY Yao, Y Wang, YL Wu… - Journal of neural …, 2014 - Springer
To evaluate the clinical importance of cerebrospinal fluid (CSF) phosphorylated tau 181 (p-
tau 181) in mild cognitive impairment (MCI), Alzheimer's disease (AD) and other dementias …

[HTML][HTML] Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease

S Janelidze, E Stomrud, R Smith, S Palmqvist… - Nature …, 2020 - nature.com
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established
biomarker of Alzheimer's disease (AD), reflecting abnormal tau metabolism in the brain …

[HTML][HTML] Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease

F Gonzalez-Ortiz, BE Kirsebom, J Contador… - Nature …, 2024 - nature.com
Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration
could identify individuals at risk for cognitive decline in Alzheimer's disease (AD). In blood …