Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a
conserved family of nicotinamide adenine dinucleotide-dependent protein lysine …

SIRT1 is an evolutionarily conserved protein deacetylase that modulates stress response,
cellular metabolism and aging in model organisms. While SIRT1 exerts beneficial effects in …

The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven
mammalian proteins, SIRT1–7. Many of the sirtuin isoforms also deacetylate nonhistone …

Sirtuin 1 (SIRT1), an NAD+‐dependent histone/protein deacetylase, has multifaceted
functions in various biological events such as inflammation, aging, and energy metabolism …

Several studies have reported that the overexpression of Sirtuin 1 (SIRT1) was associated
with poor prognosis in various human cancers. However, little is known regarding the …

Seven Sirtuin family members (SIRT1-7), comprising a family of NAD+-dependent protein
deacetylases and ADP-ribosyltransferases, are key proteins that regulate multiple …

Sirtuins are mammalian homologs of yeast silent information regulator two (SIRT) and are a
highly conserved family of proteins, which act as nicotinamide adenine dinucleotide (NAD+) …

Abstract Background Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in
cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast …

Abstract Sirtuin1 (SIRT1) is a mammalian NAD+-dependent type III deacetylase that plays
paramount roles in diverse cellular processes. The nucleocytoplasmic shuttling of SIRT1 …

Several members of the sirtuin family (SIRT1-7), which are a highly conserved family of
NAD+-dependent enzymes, play an important role in tumor formation. Recent studies …