[PDF][PDF] Research progress of Sirtuin4 in cancer
Y Bai, J Yang, Y Cui, Y Yao, F Wu, C Liu, X Fan… - Frontiers in …, 2021 - frontiersin.org
Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a
conserved family of nicotinamide adenine dinucleotide-dependent protein lysine …
conserved family of nicotinamide adenine dinucleotide-dependent protein lysine …
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene
SIRT1 is an evolutionarily conserved protein deacetylase that modulates stress response,
cellular metabolism and aging in model organisms. While SIRT1 exerts beneficial effects in …
cellular metabolism and aging in model organisms. While SIRT1 exerts beneficial effects in …
Sirtuin 1 (SIRT1) the misunderstood HDAC
W Stünkel, RM Campbell - Journal of biomolecular screening, 2011 - journals.sagepub.com
The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven
mammalian proteins, SIRT1–7. Many of the sirtuin isoforms also deacetylate nonhistone …
mammalian proteins, SIRT1–7. Many of the sirtuin isoforms also deacetylate nonhistone …
JNK‐mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation‐dependent activation of Snail
Sirtuin 1 (SIRT1), an NAD+‐dependent histone/protein deacetylase, has multifaceted
functions in various biological events such as inflammation, aging, and energy metabolism …
functions in various biological events such as inflammation, aging, and energy metabolism …
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
C Li, L Wang, L Zheng, X Zhan, B Xu… - OncoTargets and …, 2015 - Taylor & Francis
Several studies have reported that the overexpression of Sirtuin 1 (SIRT1) was associated
with poor prognosis in various human cancers. However, little is known regarding the …
with poor prognosis in various human cancers. However, little is known regarding the …
Regulation of SIRT2 levels for human non-small cell lung cancer therapy
Seven Sirtuin family members (SIRT1-7), comprising a family of NAD+-dependent protein
deacetylases and ADP-ribosyltransferases, are key proteins that regulate multiple …
deacetylases and ADP-ribosyltransferases, are key proteins that regulate multiple …
Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer
C Wang, Y Liu, Y Zhu, C Kong - Oncology Letters, 2020 - spandidos-publications.com
Sirtuins are mammalian homologs of yeast silent information regulator two (SIRT) and are a
highly conserved family of proteins, which act as nicotinamide adenine dinucleotide (NAD+) …
highly conserved family of proteins, which act as nicotinamide adenine dinucleotide (NAD+) …
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
P Becherini, I Caffa, F Piacente, P Damonte… - Cancer & …, 2021 - Springer
Abstract Background Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in
cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast …
cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast …
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial–mesenchymal transition in ovarian carcinoma
T Yang, R Zhou, S Yu, S Yu, Z Cui, P Hu, J Liu… - Molecular and cellular …, 2019 - Springer
Abstract Sirtuin1 (SIRT1) is a mammalian NAD+-dependent type III deacetylase that plays
paramount roles in diverse cellular processes. The nucleocytoplasmic shuttling of SIRT1 …
paramount roles in diverse cellular processes. The nucleocytoplasmic shuttling of SIRT1 …
[HTML][HTML] Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer
G Huang, J Cheng, F Yu, X Liu, C Yuan… - Oncology …, 2016 - spandidos-publications.com
Several members of the sirtuin family (SIRT1-7), which are a highly conserved family of
NAD+-dependent enzymes, play an important role in tumor formation. Recent studies …
NAD+-dependent enzymes, play an important role in tumor formation. Recent studies …