The two-faced role of SIRT6 in cancer
Simple Summary Cancer therapy relies on the employment of different strategies aimed at
inducing cancer cell death through different mechanisms, including DNA damage and …
inducing cancer cell death through different mechanisms, including DNA damage and …
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis
Y Zhou, S Cheng, S Chen, Y Zhao - OncoTargets and therapy, 2018 - Taylor & Francis
Background Several studies have explored the prognostic value of sirtuin 3 (SIRT3) in
various cancers, but obtained inconsistent results. The current systematic review and meta …
various cancers, but obtained inconsistent results. The current systematic review and meta …
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
Sirtuins belong to the family of class III histone deacetylases; its role in neoplasia is
controversial as both tumor-suppressive and promoting functions have been reported. There …
controversial as both tumor-suppressive and promoting functions have been reported. There …
Sorting out functions of sirtuins in cancer
M Roth, WY Chen - Oncogene, 2014 - nature.com
Abstract The sirtuins (SIRT 1–7) comprise a family of NAD+-dependent protein-modifying
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
The increased expression of SIRT1 has recently been identified in numerous human tumors
and a possible correlation with c-Myc oncogene has been proposed. However, it remains …
and a possible correlation with c-Myc oncogene has been proposed. However, it remains …
Multifaceted modulation of SIRT1 in cancer and inflammation
H Yang, Y Bi, L Xue, J Wang, Y Lu… - Critical Reviews™ in …, 2015 - dl.begellhouse.com
ABSTRACT SIRT1 is a highly conserved NAD+-dependent protein deacetylase that is
involved in diverse cellular processes. SIRT1 can deacetylate not only histones, but also a …
involved in diverse cellular processes. SIRT1 can deacetylate not only histones, but also a …
Differential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver
R Al-Bahrani, D Tuertcher, S Zailaie… - Annals of Clinical & …, 2015 - Assoc Clin Scientists
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are two major liver
malignancies. Although some phenotypic overlap is known, HCC and CCA are usually …
malignancies. Although some phenotypic overlap is known, HCC and CCA are usually …
Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer
TY Alhazzazi, P Kamarajan, N Joo, JY Huang… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Several sirtuin family members (SIRT1‐7), which are evolutionarily
conserved NAD‐dependent deacetylases, play an important role in carcinogenesis …
conserved NAD‐dependent deacetylases, play an important role in carcinogenesis …
SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
HC Chen, YM Jeng, RH Yuan, HC Hsu… - Annals of surgical …, 2012 - Springer
Background SIRT1 is a NAD+-dependent deacetylase that plays crucial roles in many
biological processes, including stress response, apoptosis, cellular metabolism, adaptation …
biological processes, including stress response, apoptosis, cellular metabolism, adaptation …
Anticancer agents targeted to sirtuins
T Kozako, T Suzuki, M Yoshimitsu, N Arima, S Honda… - Molecules, 2014 - mdpi.com
Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are
seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension …
seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension …