Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human
cancers, where they display both oncogenic and tumor-suppressive properties depending …

Sirtuins, commonly referred to as SIRTs, are a family of seven mammalian NAD+-dependent
deacetylases implicated in the regulation of critical biological processes, including …

Four different classes of HDACs have been identified in humans so far. Classes I, II and IV
are zinc-dependent amidohydrolases, while III is a family of phylogenetically conserved …

Abstract Background Sirtuin 1 (SIRT1) regulates DNA repair and metabolism by
deacetylating target proteins. SIRT1 may be oncogenic because its overexpression has …

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent protein lysine modifying enzymes with deacetylase, adenosine …

Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide
(NAD+)-dependent deacetylase, and has been reported to serve diverse roles in various …

Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A
new report sheds light on the function of SIRT7, the least understood member of the Sirtuin …

Hepatocellular carcinoma (HCC) is one of the most common neoplasms, and metastasis is
the most important feature for HCC-related deaths. Mounting evidence implies the dynamic …

Malignant melanoma is the most aggressive skin cancer and can only be cured if detected
early. Unfortunately, later stages of the disease do not guarantee success due to the rapid …

Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …