[HTML][HTML] Dual tumor suppressor and tumor promoter action of sirtuins in determining malignant phenotype
V Carafa, L Altucci, A Nebbioso - Frontiers in pharmacology, 2019 - frontiersin.org
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human
cancers, where they display both oncogenic and tumor-suppressive properties depending …
cancers, where they display both oncogenic and tumor-suppressive properties depending …
Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer
Sirtuins, commonly referred to as SIRTs, are a family of seven mammalian NAD+-dependent
deacetylases implicated in the regulation of critical biological processes, including …
deacetylases implicated in the regulation of critical biological processes, including …
Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins
G Botta, LP De Santis… - Current medicinal …, 2012 - ingentaconnect.com
Four different classes of HDACs have been identified in humans so far. Classes I, II and IV
are zinc-dependent amidohydrolases, while III is a family of phylogenetically conserved …
are zinc-dependent amidohydrolases, while III is a family of phylogenetically conserved …
[HTML][HTML] SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
MC Ma, TJ Chiu, HI Lu, WT Huang, CM Lo… - Journal of …, 2018 - Springer
Abstract Background Sirtuin 1 (SIRT1) regulates DNA repair and metabolism by
deacetylating target proteins. SIRT1 may be oncogenic because its overexpression has …
deacetylating target proteins. SIRT1 may be oncogenic because its overexpression has …
The emerging and diverse roles of sirtuins in cancer: a clinical perspective
H Yuan, L Su, WY Chen - OncoTargets and therapy, 2013 - Taylor & Francis
Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent protein lysine modifying enzymes with deacetylase, adenosine …
dependent protein lysine modifying enzymes with deacetylase, adenosine …
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
SH Jang, KW Min, SS Paik, KS Jang - Journal of clinical pathology, 2012 - jcp.bmj.com
Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide
(NAD+)-dependent deacetylase, and has been reported to serve diverse roles in various …
(NAD+)-dependent deacetylase, and has been reported to serve diverse roles in various …
[HTML][HTML] The controversial role of Sirtuins in tumorigenesis—SIRT7 joins the debate
Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A
new report sheds light on the function of SIRT7, the least understood member of the Sirtuin …
new report sheds light on the function of SIRT7, the least understood member of the Sirtuin …
[HTML][HTML] Downregulation of SIRT2 inhibits invasion of hepatocellular carcinoma by inhibiting energy metabolism
S Huang, Z Zhao, D Tang, Q Zhou, Y Li, L Zhou… - Translational …, 2017 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common neoplasms, and metastasis is
the most important feature for HCC-related deaths. Mounting evidence implies the dynamic …
the most important feature for HCC-related deaths. Mounting evidence implies the dynamic …
[HTML][HTML] SIRT2 contributes to the resistance of melanoma cells to the multikinase inhibitor dasatinib
I Karwaciak, A Sałkowska, K Karaś… - Cancers, 2019 - mdpi.com
Malignant melanoma is the most aggressive skin cancer and can only be cured if detected
early. Unfortunately, later stages of the disease do not guarantee success due to the rapid …
early. Unfortunately, later stages of the disease do not guarantee success due to the rapid …
[HTML][HTML] A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity
Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …