Four different classes of HDACs have been identified in humans so far. Classes I, II and IV
are zinc-dependent amidohydrolases, while III is a family of phylogenetically conserved …

Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide
(NAD+)-dependent deacetylase, and has been reported to serve diverse roles in various …

Objective: SIRT4, a mitochondria-localized sirtuin, represses glutamine metabolism by
inhibiting glutamate dehydrogenase (GDH). The current study aimed to evaluate the clinical …

Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …

Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic
pathways and play a role in several disease processes. Of the seven mammalian homologs …

Chromatin factors have emerged as the most frequently dysregulated family of proteins in
cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor …

Abstract Sirtuin 1 (SIRT1), originally identified as a longevity gene, regulates DNA repair and
metabolism by deacetylating target proteins such as p53. SIRT1 plays a key role in the …

The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains
controversial. Thus, we identified the specific role of SIRT6 in the progression of …

Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone
proteins, and its role in cancer and aging has long been studied and debated. Here we …

Abstract Sirtuins (SIRT1–7), are NAD-dependent deacetylases and ADP-ribosyl
transferases, plays a major part in carcinogenesis. The previous report suggests that in …