Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells
MC Pagliacci, M Smacchia, G Migliorati… - European Journal of …, 1994 - Elsevier
Genistein, a natural isoflavonoid phyto-oestrogen, inhibits the tyrosine kinase activity of
growth factor receptors and oncogene products, as well as the in vitro growth of some …
growth factor receptors and oncogene products, as well as the in vitro growth of some …
Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines
H Nakagawa, D Yamamoto, Y Kiyozuka… - Journal of cancer …, 2000 - Springer
Genistein, a prominent isoflavone in soy products, produced dose-and time-dependent in
vitro growth inhibition at high concentrations (at least 185 μM) with an IC 50 of 7.0–274.2 μM …
vitro growth inhibition at high concentrations (at least 185 μM) with an IC 50 of 7.0–274.2 μM …
Differences between human breast cell lines in susceptibility towards growth inhibition by genistein
K Dampier, EA Hudson, LM Howells… - British Journal of …, 2001 - nature.com
Genistein is thought to contribute to the putative breast cancer preventive activity of soya.
The mechanisms by which it arrests the growth of breast cells are incompletely understood …
The mechanisms by which it arrests the growth of breast cells are incompletely understood …
Estrogenic Effects of Genistein on the Growth of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Cells in Vitro and in Vivo
CY Hsieh, RC Santell, SZ Haslam, WG Helferich - Cancer research, 1998 - AACR
Genistein, found in soy products, is a phytochemical with several biological activities. In the
current study, our research focused on the estrogenic and proliferation-inducing activity of …
current study, our research focused on the estrogenic and proliferation-inducing activity of …
Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro
L Fioravanti, V Cappelletti, P Miodini, E Ronchi… - Cancer letters, 1998 - Elsevier
Genistein significantly inhibited cell growth (IC50 around 10 μM) of MCF-7, MDAMB-231 and
HBL-100 cell lines, but not of skin-derived fibroblasts and counteracted the growth …
HBL-100 cell lines, but not of skin-derived fibroblasts and counteracted the growth …
[HTML][HTML] Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice
RC Santell, N Kieu, WG Helferich - The Journal of nutrition, 2000 - Elsevier
The studies presented were conducted to assess the effect of the soy isoflavone genistein
on proliferation of estrogen-independent human breast cancer cells (MDA-MB-231) in vitro …
on proliferation of estrogen-independent human breast cancer cells (MDA-MB-231) in vitro …
Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro
DT Zava, G Duwe - 1997 - Taylor & Francis
Experimental and epidemiologic studies support the view that soyfoods prevent cancer as
well as diseases and symptoms associated with estrogen deficiency. Recent research …
well as diseases and symptoms associated with estrogen deficiency. Recent research …
Physiological concentrations of genistein and 17β-estradiol inhibit MDA-MB-231 breast cancer cell growth by increasing BAX/BCL-2 and reducing pERK1/2
TT Rajah, KJ Peine, N Du, CA Serret… - Anticancer …, 2012 - ar.iiarjournals.org
Aim: The aim of the present study was to identify the mechanism by which genistein and 17β-
estradiol inhibit proliferation of MDA-MB-231 breast cancer cells. Materials and Methods …
estradiol inhibit proliferation of MDA-MB-231 breast cancer cells. Materials and Methods …
Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells
WF Chen, MS Wong - The Journal of Clinical Endocrinology & …, 2004 - academic.oup.com
Physiological concentration of genistein, a natural isoflavonoid phytoestrogen, stimulates
human breast cancer (MCF-7) cells proliferation. In this study, we hypothesize that low …
human breast cancer (MCF-7) cells proliferation. In this study, we hypothesize that low …
Genistein in the presence of 17β-estradiol inhibits proliferation of ERβ breast cancer cells
TT Rajah, N Du, N Drews, R Cohn - Pharmacology, 2009 - karger.com
Abstract Background/Aim: Genistein, a soy component, has been shown to have a biphasic
proliferative effect in breast cancer cells, inhibiting in vitro cell proliferation at high …
proliferative effect in breast cancer cells, inhibiting in vitro cell proliferation at high …
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