Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index
Aims/hypothesis The euglycaemic–hyperinsulinaemic clamp is the gold-standard method for
measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices …
measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices …
Selection of the appropriate method for the assessment of insulin resistance
Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are
many methods available for estimation of insulin resistance which range from complex …
many methods available for estimation of insulin resistance which range from complex …
Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes
JM Olefsky, OG Kolterman - The American journal of medicine, 1981 - Elsevier
Insulin resistance is a characteristic feature of both obesity and noninsulin-dependent
diabetes mellitus. In general, the causes of insulin resistance can be placed into three …
diabetes mellitus. In general, the causes of insulin resistance can be placed into three …
Evaluation of surrogate measures of insulin sensitivity-correlation with gold standard is not enough
A Rudvik, M Månsson - BMC medical research methodology, 2018 - Springer
Background Impaired insulin sensitivity is a key abnormality underlying the development of
type 2 diabetes. Measuring insulin sensitivity is therefore of importance in identifying …
type 2 diabetes. Measuring insulin sensitivity is therefore of importance in identifying …
Biomarkers of insulin sensitivity and insulin resistance: Past, present and future
SE Park, CY Park, G Sweeney - Critical reviews in clinical …, 2015 - Taylor & Francis
Insulin resistance in insulin target tissues including liver, skeletal muscle and adipose tissue
is an early step in the progression towards type 2 diabetes. Accurate diagnostic parameters …
is an early step in the progression towards type 2 diabetes. Accurate diagnostic parameters …
Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity
D Tripathy, P Almgren, T Tuomi, L Groop - Diabetes care, 2004 - Am Diabetes Assoc
OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures
of insulin sensitivity and insulin secretion. RESEARCH DESIGN AND METHODS—The …
of insulin sensitivity and insulin secretion. RESEARCH DESIGN AND METHODS—The …
Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction
CR Kahn - Metabolism, 1978 - Elsevier
Insulin resistance may be said to exist whenever normal concentrations of insulin produce a
less than normal biologic response. Hormone resistant states may be divided into those due …
less than normal biologic response. Hormone resistant states may be divided into those due …
Toward physiological understanding of glucose tolerance: minimal-model approach
RN Bergman - Diabetes, 1989 - Am Diabetes Assoc
Glucose tolerance depends on a complex interaction among insulin secretion from the β-
cells, clearance of the hormone, and the actions of insulin to accelerate glucose …
cells, clearance of the hormone, and the actions of insulin to accelerate glucose …
Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state
A Avignon, C Boegner, D Mariano-Goulart… - International journal of …, 1999 - nature.com
OBJECTIVE: To compare insulin sensitivity indexes derived from plasma insulin (I) and
glucose (G) in the basal state (Sib) and at the second hour (I2h and G2h) of an oral glucose …
glucose (G) in the basal state (Sib) and at the second hour (I2h and G2h) of an oral glucose …
Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels
F Belfiore, S Iannello, G Volpicelli - Molecular genetics and metabolism, 1998 - Elsevier
Insulin Sensitivity Indices for glycemia [ISI (gly)] and blood FFA [ISI (ffa)] can be calculated
with the formulas: ISI (gly)= 2/[(INSp× GLYp)+ 1], and ISI (ffa)= 2/[(INSp× FFAp)+ 1], where …
with the formulas: ISI (gly)= 2/[(INSp× GLYp)+ 1], and ISI (ffa)= 2/[(INSp× FFAp)+ 1], where …