Aims/hypothesis The euglycaemic–hyperinsulinaemic clamp is the gold-standard method for
measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices …

Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are
many methods available for estimation of insulin resistance which range from complex …

Insulin resistance is a characteristic feature of both obesity and noninsulin-dependent
diabetes mellitus. In general, the causes of insulin resistance can be placed into three …

Background Impaired insulin sensitivity is a key abnormality underlying the development of
type 2 diabetes. Measuring insulin sensitivity is therefore of importance in identifying …

Insulin resistance in insulin target tissues including liver, skeletal muscle and adipose tissue
is an early step in the progression towards type 2 diabetes. Accurate diagnostic parameters …

OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures
of insulin sensitivity and insulin secretion. RESEARCH DESIGN AND METHODS—The …

Insulin resistance may be said to exist whenever normal concentrations of insulin produce a
less than normal biologic response. Hormone resistant states may be divided into those due …

Glucose tolerance depends on a complex interaction among insulin secretion from the β-
cells, clearance of the hormone, and the actions of insulin to accelerate glucose …

OBJECTIVE: To compare insulin sensitivity indexes derived from plasma insulin (I) and
glucose (G) in the basal state (Sib) and at the second hour (I2h and G2h) of an oral glucose …

Insulin Sensitivity Indices for glycemia [ISI (gly)] and blood FFA [ISI (ffa)] can be calculated
with the formulas: ISI (gly)= 2/[(INSp× GLYp)+ 1], and ISI (ffa)= 2/[(INSp× FFAp)+ 1], where …