Insulin signaling at the target tissue results in a large array of biological outcomes. These
events are essential for normal growth and development and for normal homeostasis of …

OBJECTIVE—To investigate whether the quantitative insulin sensitivity check index
(QUICKI) and the reciprocal index of homeostasis model assessment (1/HOMA-IR) derived …

The traditional methods for the assessment of insulin sensitivity yield only a single index, not
the whole dose-response curve information. This curve is typically characterized by a …

The Bergman Minimal Model enables estimation of two key indices of glucose/insulin
dynamics: glucose effectiveness and insulin sensitivity. In this paper we describe MINMOD …

Studies were done to determine whether the minimal model approach and the glucose
clamp measure equivalent indices of insulin action. Euglycemic glucose clamps (glucose, G …

I. Origin of the Insulin Sensitivity Concept H ISTORICALLY, the study of the pathogenesis of
diabetes mellitus was in the traditional pattern of endocrinology: removal of the pancreas led …

Context: Type 1 diabetes is known to be a state of insulin resistance; however, the tissues
involved in whole-body insulin resistance are less well known. It is unclear whether insulin …

An exogenous insulin administration-modified, frequently sampled iv glucose tolerance test
(FSIGT) for application in insulin-dependent diabetic patients (IDDM) to allow for estimation …

With the development of insulin resistance (IR), there is a compensatory increase in the
plasma insulin response to offset the defect in insulin action to maintain normal glucose …

The homeostasis model assessment (HOMA) has been extensively used as a reliable
surrogate marker for measuring insulin resistance in patients with diabetes mellitus and in …