Diabetes patients cannot complete effective blood glucose regulation due to their impaired
pancreatic function. At present, subcutaneous insulin injection is the only treatment for …

The development of a self-regulated minimally invasive system for insulin delivery can be
considered as the holy grail in the field of diabetes mellitus. A delivery system capable of …

Limited drug loading and incomplete drug release are two major obstacles that traditional
polymeric microneedles (MNs) have to overcome. For smart controlled-release MNs, since …

Developing glucose‐responsive microneedle patches with features of simple preparation,
high insulin loading, and safety has a great contribution to the treatment of diabetic patients …

Microneedle technology relates to pharmacy, polymer chemistry and micromachining.
Microneedle can effectively deliver insulin into systemic circulation across the skin. This …

Most reported microneedle patches still suffer from a complicated preparation process and
insufficient loading capacity for the glucose‐responsive delivery system. Herein, based on …

A closed-loop system imitating the function of pancreatic cells, connected to microneedles
(MNs) that automatically “release” insulin in response to the blood glucose (BG) levels …

Insulin administration at mealtimes for the control of postprandial glucose is a major part of
basal-bolus insulin therapy; however, painful subcutaneous (SC) injections lead to poor …

As a painless and minimally invasive method of self-administration, microneedle is very
promising to replace subcutaneous injection of insulin for type I diabetes treatment. Since …

Transdermal microneedle-mediated glucose-responsive insulin delivery systems can
modulate insulin release based on fluctuations in blood glucose levels, thus maintaining …