The effect of particle size, location and season on the toxicity of urban and rural particulate matter

J Mirowsky, C Hickey, L Horton, M Blaustein… - Inhalation …, 2013 - Taylor & Francis
Particulate matter (PM) varies in chemical composition and mass concentration based on a
number of factors including location, season, source and particle size. The aim of this study …

The role of soluble components in ambient fine particles-induced changes in human lungs and blood

YCT Huang, AJ Ghio, J Stonehuerner… - Inhalation …, 2003 - Taylor & Francis
Normal individuals developed pulmonary neutrophilic inflammation and increased blood
fibrinogen following inhalation of concentrated ambient particles (CAPS). In this study, we …

Winter fine particulate matter from Milan induces morphological and functional alterations in human pulmonary epithelial cells (A549)

M Gualtieri, P Mantecca, V Corvaja, E Longhin… - Toxicology letters, 2009 - Elsevier
Samples of PM2. 5 were gravimetrically collected during the winter 2005/2006 in the urban
area of Milan (North Italy). Samples were chemically characterized and the particles were …

Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production

S Becker, JM Soukup, MI Gilmour, RB Devlin - Toxicology and applied …, 1996 - Elsevier
A number of epidemiological studies have associated increased cardiopulmonary mortality
and hospital admissions with episodes of high particulate air pollution. Inhaled particles …

Concordance Between In Vitro and In Vivo Dosimetry in the Proinflammatory Effects of Low-Toxicity, Low-Solubility Particles: The Key Role of the Proximal Alveolar …

K Donaldson, PJA Borm, G Oberdorster… - Inhalation …, 2008 - Taylor & Francis
We previously demonstrated the importance of the surface area burden as the key dose
metric in the elicitation of inflammation in rat lungs by low-solubility, low-toxicity particles …

Role of Paris PM2. 5 components in the pro-inflammatory response induced in airway epithelial cells

A Baulig, S Singh, A Marchand, R Schins, R Barouki… - Toxicology, 2009 - Elsevier
Particulate matter (PM) is suspected to play a role in environmentally-induced pathologies.
Due to its complex composition, the contribution of each PM components to PM-induced …

Short-term effects of particulate matter: an inflammatory mechanism?

ML Scapellato, M Lotti - Critical reviews in toxicology, 2007 - Taylor & Francis
“Would you tell me please, which way I ought to go from here,” asked Alice.“That depends a
good deal on where you want to go to,” said the cat.(Lewis Carroll, Alice's Adventures in …

Health effects and time course of particulate matter on the cardiopulmonary system in rats with lung inflammation

MMW Ulrich, GM Alink, P Kumarathasan… - Journal of Toxicology …, 2002 - Taylor & Francis
Recent epidemiological studies associate health effects and particulate matter in ambient
air. Exacerbation of the particle-induced inflammation can be a mechanism responsible for …

Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines

DM Brown, MR Wilson, W MacNee, V Stone… - Toxicology and applied …, 2001 - Elsevier
Studies into the effects of ultrafine particles in the lung have shown adverse effects
considered to be due in part to the particle size. Air pollution particles (PM10) are associated …

Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.

XY Li, PS Gilmour, K Donaldson, W MacNee - Thorax, 1996 - thorax.bmj.com
BACKGROUND: Epidemiological evidence has implicated fine particulate air pollution,
particularly particles less than 10 microns in diameter (PM10), in the development of …