Particle size, chemical composition, seasons of the year and urban, rural or remote site origins as determinants of biological effects of particulate matter on pulmonary …

MG Perrone, M Gualtieri, V Consonni, L Ferrero… - Environmental …, 2013 - Elsevier
Particulate matter (PM), a complex mix of chemical compounds, results to be associated with
various health effects. However there is still lack of information on the impact of its different …

Ultrafine particles cause cytoskeletal dysfunctions in macrophages

W Möller, T Hofer, A Ziesenis, E Karg… - Toxicology and applied …, 2002 - Elsevier
Essential cytoskeletal functions of macrophages are migration, phagocytosis of foreign
materials, and intracellular transport and digestion The influence of fine and ultrafine test …

Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis

A Nemmar, MF Hoylaerts, PHM Hoet… - Toxicology and applied …, 2003 - Elsevier
Particulate air pollution is associated with cardiorespiratory effects and ultrafine particles
(UFPs, diameter< 100 nm) are believed to play an important role. We studied the acute (1 h) …

Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin

A CP Elder, R Gelein, J N. Finkelstein, C Cox… - Inhalation …, 2000 - Taylor & Francis
Epidemiological studies demonstrate associations between increasing levels of ambient
particles and morbidity in the elderly with cardiopulmonary disease. Such findings have …

Source-specific fine particulate air pollution and systemic inflammation in ischaemic heart disease patients

T Siponen, T Yli-Tuomi, M Aurela, H Dufva… - Occupational and …, 2015 - oem.bmj.com
Objective To compare short-term effects of fine particles (PM2. 5; aerodynamic diameter< 2.5
µm) from different sources on the blood levels of markers of systemic inflammation. Methods …

The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area

C Monteiller, L Tran, W MacNee, S Faux… - Occupational and …, 2007 - oem.bmj.com
Objective: Rats exposed to high airborne mass concentrations of low-solubility low-toxicity
particles (LSLTP) have been reported to develop lung disease such as fibrosis and lung …

In vitro inflammatory and cytotoxic effects of size-segregated particulate samples collected during long-range transport of wildfire smoke to Helsinki

PI Jalava, RO Salonen, AI Hälinen, P Penttinen… - Toxicology and applied …, 2006 - Elsevier
The impact of long-range transport (LRT) episodes of wildfire smoke on the inflammogenic
and cytotoxic activity of urban air particles was investigated in the mouse RAW 264.7 …

Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects

PJ Jagielo, PS Thorne, JL Watt, KL Frees, TJ Quinn… - Chest, 1996 - Elsevier
Study objective To compare the physiologic and inflammatory response following inhalation
of corn dust extract (CDE) and lipopolysaccharide (LPS) solutions in normal subjects …

Oxidant generation by particulate matter: from biologically effective dose to a promising, novel metric

PJA Borm, F Kelly, N Künzli, RPF Schins… - Occupational and …, 2007 - oem.bmj.com
The classic toxicology paradigm between exposure and response provides the justification
for accurate measurement of exposure to underpin good epidemiological studies aimed at …

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms

AM Scherbart, J Langer, A Bushmelev… - Particle and fibre …, 2011 - Springer
Inhalation of (nano) particles may lead to pulmonary inflammation. However, the precise
mechanisms of particle uptake and generation of inflammatory mediators by alveolar …