Amphetamines are highly addictive drugs that have pronounced effects on emotional and
cognitive behavior in humans. These effects are mediated through their potent dopaminergic …

Many studies indicate a role of the cerebral dopaminergic reward system in addiction.
Motivated by these findings, we examined in opiate addicts whether brain regions involved …

Cannabis is one of the most used drugs of abuse. It affects the brain reward system in
animals, and has proven rewarding and addictive potential in humans. We used functional …

Transmission of reward signals is a function of dopamine, a neurotransmitter known to be
involved in the mechanism of psychosis. Using functional magnetic resonance imaging …

The use of functional magnetic resonance imaging (fMRI) in animal models of cocaine
addiction is an invaluable tool for investigating the neuroadaptations that lead to this …

Objective Frontostriatal circuitry is critical to learning processes, and its disruption may
underlie maladaptive decision making and the generation of psychotic symptoms in …

Drug abuse and dependence define behavioral states involving increased allocation of
behavior towards drug seeking and taking at the expense of more appropriate behavioral …

Research suggests that psychostimulants can physiologically alter dopamine kinetics in the
ventral striatum (VS) and psychologically enhance mood and attention. Using event-related …

Aims The purpose of this review is to summarize the neural substrate dysfunctions and
disrupted cognitive, affective and experiential processes observed in methamphetamine and …

The rewarding effects of drugs of abuse are thought to be dependent on the
mesocorticolimbic dopamine system, which originates in the ventral tegmental area (VTA) …