[HTML][HTML] Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases
B Mailhot, M Christin, N Tessandier… - Journal of Experimental …, 2020 - rupress.org
Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …
Cytokines in pain: harnessing endogenous anti-inflammatory signaling for improved pain management
AG Vanderwall, ED Milligan - Frontiers in immunology, 2019 - frontiersin.org
Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …
Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain
N Kiguchi, Y Kobayashi, F Saika, H Sakaguchi… - Pain, 2015 - journals.lww.com
There is increasing evidence that inflammatory (M1-polarized) macrophages drive the
nonresolving neuroinflammation that causes neuropathic pain after nerve injury. As …
nonresolving neuroinflammation that causes neuropathic pain after nerve injury. As …
Role of interleukin-1β during pain and inflammation
K Ren, R Torres - Brain research reviews, 2009 - Elsevier
The cytokine cascade in pain and inflammatory processes is a tremendously complex
system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory …
system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory …
Interleukin-1αβ gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain
P Honore, CL Wade, C Zhong, RR Harris, C Wu… - Behavioural brain …, 2006 - Elsevier
The pro-inflammatory cytokine interleukin-1 (IL-1) has been implicated in both inflammatory
processes and nociceptive neurotransmission. To further investigate the role of IL-1 in …
processes and nociceptive neurotransmission. To further investigate the role of IL-1 in …
Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects
The cytokine interleukin-1 (IL-1) has been implicated in modulation of pain perception under
various inflammatory conditions. The present study examined the hypothesis that IL-1 …
various inflammatory conditions. The present study examined the hypothesis that IL-1 …
Spinal interleukin‐1β in a mouse model of arthritis and joint pain
PM Fiorentino, RH Tallents, JNH Miller… - … : Official Journal of …, 2008 - Wiley Online Library
Objective Pain from arthritis has been associated with peripheral sensitization of primary
sensory afferents and the development of inflammation at the dorsal horns. This study was …
sensory afferents and the development of inflammation at the dorsal horns. This study was …
Chronic neuropathic pain–like behavior and brain‐borne IL‐1β
A del Rey, AV Apkarian, M Martina… - Annals of the New …, 2012 - Wiley Online Library
Neuropathic pain in animals results in increased IL‐1β expression in the damaged nerve,
the dorsal root ganglia, and the spinal cord. Here, we discuss our results showing that this …
the dorsal root ganglia, and the spinal cord. Here, we discuss our results showing that this …
Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice
Peripheral nerve injury may lead to neuropathic pain, which is often associated with
mechanical and thermal allodynia, ectopic discharge of from injured nerves and from the …
mechanical and thermal allodynia, ectopic discharge of from injured nerves and from the …
Pain: a review of interleukin-6 and its roles in the pain of rheumatoid arthritis
A Sebba - Open access rheumatology: research and reviews, 2021 - Taylor & Francis
Pain is a major and common symptom reported as a top priority in patients with rheumatoid
arthritis (RA). Intuitively, RA-related pain is often considered to be a natural consequence of …
arthritis (RA). Intuitively, RA-related pain is often considered to be a natural consequence of …