Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …

Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …

There is increasing evidence that inflammatory (M1-polarized) macrophages drive the
nonresolving neuroinflammation that causes neuropathic pain after nerve injury. As …

The cytokine cascade in pain and inflammatory processes is a tremendously complex
system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory …

The pro-inflammatory cytokine interleukin-1 (IL-1) has been implicated in both inflammatory
processes and nociceptive neurotransmission. To further investigate the role of IL-1 in …

The cytokine interleukin-1 (IL-1) has been implicated in modulation of pain perception under
various inflammatory conditions. The present study examined the hypothesis that IL-1 …

Objective Pain from arthritis has been associated with peripheral sensitization of primary
sensory afferents and the development of inflammation at the dorsal horns. This study was …

Neuropathic pain in animals results in increased IL‐1β expression in the damaged nerve,
the dorsal root ganglia, and the spinal cord. Here, we discuss our results showing that this …

Peripheral nerve injury may lead to neuropathic pain, which is often associated with
mechanical and thermal allodynia, ectopic discharge of from injured nerves and from the …

Pain is a major and common symptom reported as a top priority in patients with rheumatoid
arthritis (RA). Intuitively, RA-related pain is often considered to be a natural consequence of …