Background We aim to test the hypothesis that high plasma YKL-40 is associated with short
progression-free survival (PFS) and overall survival (OS) in patients with metastatic …

Plasma YKL‐40 is high in patients with cancer and in individuals who later develop cancer.
Whether YKL‐40 is only a marker or indeed a cause of cancer is presently unknown. We …

Background YKL-40 is a member of the mammalian chitinase-like proteins. Elevated serum
YKL-40 levels in patients with gastrointestinal cancer at time of diagnosis are associated …

A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds
of tumors. It is predicted that an inherent correlation exists between survivals of cancer …

Objectives YKL-40 is a novel inflammatory serum protein shown to be associated with the
presence and prognosis of several malignancies. However, its prognostic relevance has not …

Objectives: A potential role in cancer biology is suggested for YKL‐40 (CHI3L1, HC gp‐39).
The purpose of this study was to evaluate the clinical value of serum YKL‐40 (sYKL‐40) in …

Purpose: Biomarkers can facilitate diagnosis, monitor treatment response, and assess
prognosis in some patients with cancer. YKL-40 and matrix metalloproteinase-9 (MMP-9) …

Background YKL-40 has been implicated as a mediator of collagen synthesis and
extracellular matrix re-modeling as well as mitogenesis. Elevated serum levels of YKL-40 …

We have identified a potential serum marker for glioblastoma multiforme (GBM)
usingmicroarray analysis from samples of GBM. We compared the gene expression profile …

This study investigates the prognostic and predictive value of YKL-40 in stage IIB–III
melanoma patients who were randomized to adjuvant interferon α-2b (IFN) or observation …