Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates
CM Cremeans, E Gruley, DJ Kyle, MC Ko - Journal of Pharmacology and …, 2012 - ASPET
Buprenorphine is known as a μ-opioid peptide (MOP) receptor agonist, but its
antinociception is compromised by the activation of nociceptin/orphanin FQ peptide (NOP) …
antinociception is compromised by the activation of nociceptin/orphanin FQ peptide (NOP) …
Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/μ-opioid receptor agonists
TV Khroyan, WE Polgar, F Jiang, NT Zaveri… - Journal of Pharmacology …, 2009 - ASPET
Activation of brain nociceptin/orphanin FQ (NOP) receptors leads to attenuation of μ-opioid
receptor (MOP receptor)-mediated antinociception. Buprenorphine, a high-affinity partial …
receptor (MOP receptor)-mediated antinociception. Buprenorphine, a high-affinity partial …
Buprenorphine-induced antinociception is mediated by μ-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
K Lutfy, S Eitan, CD Bryant, YC Yang… - Journal of …, 2003 - Soc Neuroscience
Buprenorphine is a mixed opioid receptor agonist-antagonist used clinically for maintenance
therapy in opiate addicts and pain management. Dose-response curves for buprenorphine …
therapy in opiate addicts and pain management. Dose-response curves for buprenorphine …
[HTML][HTML] Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys
MC Ko, JH Woods, WE Fantegrossi… - …, 2009 - nature.com
Behavioral effects of a nonpeptidic NOP (nociceptin/orphanin FQ Peptide) receptor agonist,
Ro 64-6198, have not been studied in primate species. The aim of the study was to verify the …
Ro 64-6198, have not been studied in primate species. The aim of the study was to verify the …
Buprenorphine exerts its antinocicepttve activity via μ1-opioid receptors
J Kamei, A Saitoh, T Suzuki, M Misawa, H Nagase… - Life sciences, 1995 - Elsevier
The mechanism of the antinociceptive effect of buprenorphine was assessed by
administering selective μ-, μ1-, δ-and κ-opioid receptor antagonists in mice. Intraperitoneal …
administering selective μ-, μ1-, δ-and κ-opioid receptor antagonists in mice. Intraperitoneal …
Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse
Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …
Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ–receptor agonist 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H …
A Hirao, A Imai, Y Sugie, Y Yamada, S Hayashi… - Journal of …, 2008 - Elsevier
Nociceptin/orphanin FQ peptide (NOP)-receptor agonists have been shown to produce
anxiolytic-like effects in rodents subjected to various behavioral assays. Recently, we …
anxiolytic-like effects in rodents subjected to various behavioral assays. Recently, we …
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Misuse of prescription opioids, opioid addiction, and overdose underscore the urgent need
for developing addiction-free effective medications for treating severe pain. Mu opioid …
for developing addiction-free effective medications for treating severe pain. Mu opioid …
The first universal opioid ligand,(2S)-2-[(5R, 6R, 7R, 14S)-N-cyclopropylmethyl-4, 5-epoxy-6, 14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3, 3-dimethylpentan-2 …
TV Khroyan, WE Polgar, G Cami-Kobeci… - … of Pharmacology and …, 2011 - ASPET
Certain behavioral features of buprenorphine, including a bell-shaped curve for
antinociception and attenuation of alcohol consumption, are thought to be mediated by …
antinociception and attenuation of alcohol consumption, are thought to be mediated by …
Nociceptin/orphanin FQ peptide receptor-related ligands as novel analgesics
N Kiguchi, H Ding, S Kishioka… - Current topics in medicinal …, 2020 - ingentaconnect.com
Despite similar distribution patterns and intracellular events observed in the
nociceptin/orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor …
nociceptin/orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor …