Mitochondrial nitric oxide synthase (mtNOS), its cellular NOS isoform, and the effects of
mitochondrially produced NO on bioenergetics have been controversial since mtNOS was …

The existence of mitochondrial nitric oxide (NO) synthase (mtNOS) has been controversial
since it was first reported in 1995. We have addressed this issue by making direct …

We used laser scanning confocal microscopy in combination with the nitric oxide (NO)‐
sensitive fluorescent dye DAF‐2 and the reactive oxygen species (ROS)‐sensitive dyes CM …

We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive,
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase
in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal …

The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …

Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP
channel activity. Recent studies show the presence of a potentionally new isoform of the …

Recent studies indicated that there is a distinct mitochondrial nitric oxide synthase (mtNOS)
enzyme, which may be identical to the other known NOS isoforms. We investigated the …

Nitric oxide (NO) inhibits the mitochondrial respiratory chain, resulting in inhibition of ATP
production, increased oxidant production and increased susceptibility to cell death. NO …

New discoveries in the last decade significantly altered our view on mitochondria. They are
no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In …