Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection
AJ Kanai, LL Pearce, PR Clemens… - Proceedings of the …, 2001 - National Acad Sciences
Mitochondrial nitric oxide synthase (mtNOS), its cellular NOS isoform, and the effects of
mitochondrially produced NO on bioenergetics have been controversial since mtNOS was …
mitochondrially produced NO on bioenergetics have been controversial since mtNOS was …
Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells
A Kanai, M Epperly, L Pearce, L Birder… - American Journal …, 2004 - journals.physiology.org
The existence of mitochondrial nitric oxide (NO) synthase (mtNOS) has been controversial
since it was first reported in 1995. We have addressed this issue by making direct …
since it was first reported in 1995. We have addressed this issue by making direct …
Characteristics and function of cardiac mitochondrial nitric oxide synthase
EN Dedkova, LA Blatter - The Journal of physiology, 2009 - Wiley Online Library
We used laser scanning confocal microscopy in combination with the nitric oxide (NO)‐
sensitive fluorescent dye DAF‐2 and the reactive oxygen species (ROS)‐sensitive dyes CM …
sensitive fluorescent dye DAF‐2 and the reactive oxygen species (ROS)‐sensitive dyes CM …
Biochemistry of mitochondrial nitric-oxide synthase
SL Elfering, TM Sarkela, C Giulivi - Journal of Biological Chemistry, 2002 - ASBMB
We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive,
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …
Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?
TE Bates, A Loesch, G Burnstock, JB Clark - Biochemical and biophysical …, 1996 - Elsevier
In this article we demonstrate the immunocytochemical localization of nitric oxide synthase
in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal …
in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal …
Oxygen dependence of mitochondrial nitric oxide synthase activity
S Alvarez, LB Valdez, T Zaobornyj, A Boveris - … and biophysical research …, 2003 - Elsevier
The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …
on O2− production was determined in rat liver, brain, and kidney submitochondrial …
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia
Z Lacza, M Puskar, JP Figueroa, J Zhang… - Free Radical Biology …, 2001 - Elsevier
Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP
channel activity. Recent studies show the presence of a potentionally new isoform of the …
channel activity. Recent studies show the presence of a potentionally new isoform of the …
Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS
Z Lacza, JA Snipes, J Zhang, EM Horváth… - Free Radical Biology …, 2003 - Elsevier
Recent studies indicated that there is a distinct mitochondrial nitric oxide synthase (mtNOS)
enzyme, which may be identical to the other known NOS isoforms. We investigated the …
enzyme, which may be identical to the other known NOS isoforms. We investigated the …
Nitric oxide and mitochondrial respiration in the heart
GC Brown, V Borutaite - Cardiovascular research, 2007 - academic.oup.com
Nitric oxide (NO) inhibits the mitochondrial respiratory chain, resulting in inhibition of ATP
production, increased oxidant production and increased susceptibility to cell death. NO …
production, increased oxidant production and increased susceptibility to cell death. NO …
[HTML][HTML] Mitochondrial nitric oxide synthase: current concepts and controversies
Z Lacza, E Pankotai, DW Busija - Frontiers in bioscience (Landmark …, 2009 - ncbi.nlm.nih.gov
New discoveries in the last decade significantly altered our view on mitochondria. They are
no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In …
no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In …