DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

DNA methylation and chromatin structure patterns are tightly linked components of the
epigenome, which regulate gene expression programming. Two contradictory changes in …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

DNA methyltransferases are promising targets for cancer therapy. In many cancer cells
promoters of tumor suppressor genes are hypermethylated, which results in gene …

Vertebrate DNA is modified by methyl moieties at the 5′-position of cytosine rings residing
in the di-nucleotide sequence CpG. Approximately 80% of CpG dinucleotide sequences are …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Hypermethylation of tumor suppressor genes is one of the most consistent hallmarks of
human cancers. This epigenetic alteration has been associated with gene silencing and …