The cytosine analogues azacytidine and decitabine are currently being developed as drugs
for epigenetic cancer therapy. Although various studies have shown that both drugs are …

Methylation of DNA is a biochemical modification that can influence gene expression and is
involved in inactivating one of the two X chromosomes in women. Evidence that has …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of
gene expression and represent valuable targets in cancer chemotherapy. A number of …

Because DNA methyltransferase (DNMT) inhibitors like azacytidine and decitabine are
known to be effective in the clinic for diseases like myelodysplastic syndromes that may …

Patterns of DNA methylation are established during embryonic development and faithfully
copied through somatic cell divisions. Based on current understanding of DNA methylation …

The unique properties of a cancer cell are acquired through a stepwise accumulation of
heritable changes in the information content of proto‐oncogenes and tumor suppressor …

Epigenetics is a kind of heritable change that involves the unaltered DNA sequence and can
have effects on gene expression. The regulatory mechanism mainly includes DNA …

Epigenetics refers to changes in a biological phenotype that are not due to an underlying
change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …