ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

P Zhang, Y Sun, L Ma - Cell cycle, 2015 - Taylor & Francis
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

ZEB1: a critical regulator of cell plasticity, DNA damage response, and therapy resistance

S Drápela, J Bouchal, MK Jolly, Z Culig… - Frontiers in molecular …, 2020 - frontiersin.org
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …

The crucial role of ZEB2: from development to epithelial‐to‐mesenchymal transition and cancer complexity

M Fardi, M Alivand, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM

X Zhang, Z Zhang, Q Zhang, Q Zhang, P Sun… - Cell death & …, 2018 - nature.com
Although zinc finger E-box binding homeobox 1 (ZEB1) has been identified as a key factor in
the regulation of breast cancer differentiation and metastasis, its potential role in modulating …

Regulation of ZEB1 function and molecular associations in tumor progression and metastasis

M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …

Pleiotropic roles for ZEB1 in cancer

J Caramel, M Ligier, A Puisieux - Cancer research, 2018 - AACR
ZEB1 is a prime element of a network of transcription factors that controls epithelial-to-
mesenchymal transition (EMT), a reversible embryonic transdifferentiation program that …

[HTML][HTML] ZEB1: catalyst of immune escape during tumor metastasis

J Lu, F Fei, C Wu, J Mei, J Xu, P Lu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers

NS Spoelstra, NG Manning, Y Higashi, D Darling… - Cancer research, 2006 - AACR
The transcription factor ZEB1 (δEF1 in mice) has been implicated in cellular processes
during development and tumor progression including epithelial to mesenchymal transition …

Zeb1 links epithelial-mesenchymal transition and cellular senescence

Y Liu, S El-Naggar, DS Darling, Y Higashi, DC Dean - 2008 - journals.biologists.com
Overexpression of zinc finger E-box binding homeobox transcription factor 1 (Zeb1) in
cancer leads to epithelial-to-mesenchymal transition (EMT) and increased metastasis. As …