BACKGROUND The treatment of metastatic melanoma remains unsatisfactory despite
encouraging results with biotherapy and combination chemotherapy. Combining these two …

The therapeutic benefit of adding interferon α (IFNα) to established single-agent and
combination chemotherapy regimens for the treatment of metastatic melanoma has not been …

Background The treatment of metastatic melanoma remains unsatisfactory despite
encouraging results with biotherapy and combination chemotherapy. Combining these two …

The majority of patients with stage I melanoma can be cured with surgery. Extension of
tumor to the regional lymph nodes portends a poor prognosis, with an expected 5-year …

The combination of cisplatin-based chemotherapy with interleukin-2 and interferon-alpha,
referred to as biochemotherapy or chemoimmunotherapy, has shown promising antitumor …

Since cytotoxic chemotherapy (BCNU, DTIC and cisplatin, tamoxifen) and interferon-
[alpha](IFN-[alpha]) have each produced responses in advanced malignant melanoma, a …

Purpose. Metastatic melanoma and current treatments are reviewed. Summary. Despite the
many advances in cancer treatment that have occurred over the last several decades, the …

PURPOSE: The combination of chemotherapy with immunotherapeutic agents such as
interleukin-2 and interferon alfa-2b has been reported to provide improved treatment results …

Systemic chemotherapy for the treatment of metastatic melanoma remains disappointing.
Nor new single agent has demonstrated promising results. The combination of cisplatin …

PURPOSE The goal of this study was to determine the therapeutic efficacy and toxicity of a
four-drug chemotherapy regimen combined with natural leukocyte interferon alfa (IFN-alpha) …