Reversal of p53‐induced cell‐cycle arrest
S Bates, ES Hickman… - … : Published in cooperation …, 1999 - Wiley Online Library
Activation of the tumor suppressor protein p53 can lead to arrest in both G1 and G2 stages of
the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the …
the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the …
Comparison of apoptotic, necrotic and clonogenic cell death and inhibition of cell growth following camptothecin and X-radiation treatment in a human melanoma and …
SS Qutob, CE Ng - Cancer chemotherapy and pharmacology, 2002 - Springer
Purpose: We evaluated apoptotic, necrotic and clonogenic cell death and inhibition of cell
growth in a human melanoma cell line (Sk-Mel-3) and a normal human fibroblast cell line …
growth in a human melanoma cell line (Sk-Mel-3) and a normal human fibroblast cell line …
Altered sensitivity of deoxyadenosine-resistant mouse leukemia L1210 cells to apoptosis induced by 7-hydroxystaurosporine.
L Somerville, JG Cory - International journal of …, 2000 - spandidos-publications.com
The deoxyadenosine-resistant mouse leukemia L1210 cell line (Y8) has previously been
shown to be more sensitive to apoptosis induced by DNA damaging agents and by protein …
shown to be more sensitive to apoptosis induced by DNA damaging agents and by protein …
UCN-01 dose-dependent inhibition of normal hyperproliferative cells in mice
AA Redkar, GG Meadows… - … journal of oncology, 2001 - spandidos-publications.com
UCN-01 is a hydroxylated derivative of staurosporine and a potent protein kinase C (PKC)
inhibitor. Interest in the potential usefulness of this compound as an anticancer drug stems …
inhibitor. Interest in the potential usefulness of this compound as an anticancer drug stems …
p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel
D Debernardis, EG Siré, P De Feudis, F Vikhanskaya… - Cancer research, 1997 - AACR
Nine human ovarian cancer cell lines that express wild-type (wt) or mutated p53 were used
to evaluate the cytotoxicity induced by paclitaxel. The IC50 calculated in the five mutated …
to evaluate the cytotoxicity induced by paclitaxel. The IC50 calculated in the five mutated …
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and …
The human leukemia cell line, HL60 is very sensitive to various apoptotic stimuli and p53-
null. The death-related cysteine proteases of the caspases family play a central role in the …
null. The death-related cysteine proteases of the caspases family play a central role in the …
Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression.
AH Cory, DH Hickerson, JG Cory - Anticancer research, 2000 - europepmc.org
An L1210 cell line (Y8) selected for resistance to deoxyadenosine contains ribonucleotide
reductase that is not subject to inhibition by dATP. In addition, the Y8 cells have other …
reductase that is not subject to inhibition by dATP. In addition, the Y8 cells have other …
Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms …
AN Tse, GK Schwartz - Cancer research, 2004 - AACR
UCN-01 is a potent inhibitor of the S-and G2-M-phase cell cycle checkpoints by targeting
chk1 and possibly chk2 kinases. It has been shown in some, but not all, instances that UCN …
chk1 and possibly chk2 kinases. It has been shown in some, but not all, instances that UCN …
Differential sensitization of two human colon cancer cell lines to the antitumor effects of irinotecan combined with 5-aza-2'-deoxycytidine
S Hakata, J Terashima, Y Shimoyama… - Oncology …, 2018 - spandidos-publications.com
Abstract Irinotecan (CPT-11) is a key therapeutic drug used in the treatment of colorectal
cancer, although acquired or constitutive resistance to CPT-11 (and its activated metabolite …
cancer, although acquired or constitutive resistance to CPT-11 (and its activated metabolite …
[HTML][HTML] Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human …
SI Lee, MK Brown, A Eastman - Biochemical pharmacology, 1999 - Elsevier
DNA-damaging agents such as cisplatin arrest cell cycle progression at either the G1, S, or
G2 phase, although the G1 arrest is seen only in cells expressing the wild-type p53 tumor …
G2 phase, although the G1 arrest is seen only in cells expressing the wild-type p53 tumor …