Apoptosis and nuclear levels of p53 protein and proliferating cell nuclear antigen in human hepatoma cells cultured with tumor promoters
Y Kaneko, A Tsukamoto - Cancer letters, 1995 - Elsevier
Anticancer drugs etoposide and mitomycin C increased nuclear p53 protein and decreased
proliferating cell nuclear antigen (PCNA) of PLC/PRF/5 human hepatoma cells. These …
proliferating cell nuclear antigen (PCNA) of PLC/PRF/5 human hepatoma cells. These …
Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation
GD Bino, S Bruno, PN Yi, Z Darzynkiewicz - Cell Proliferation, 1992 - Wiley Online Library
We have previously observed that the DNA topoisomerase I inhibitor camptothecin (CAM),
or DNA topoisomerase II inhibitors teniposide (TEN) and amsacrine (m‐AMSA) trigger …
or DNA topoisomerase II inhibitors teniposide (TEN) and amsacrine (m‐AMSA) trigger …
Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair.
A Fujimori, M Gupta, Y Hoki, Y Pommier - Molecular pharmacology, 1996 - ASPET
A camptothecin (CPT)-resistant cell line (MCF-7/C4) was established from MCF-7 cells by
mutagenic treatment with methylmethanesulfonate and selection with CPT. MCF-7/C4 is 30 …
mutagenic treatment with methylmethanesulfonate and selection with CPT. MCF-7/C4 is 30 …
In vivo studies of adenovirus-mediated p53 gene therapy for cis-platinum-resistant human ovarian tumor xenografts.
K Song, KH Cowan, BK Sinha - Oncology research, 1999 - europepmc.org
We have recently reported that mutations of the tumor suppressor p53 gene are associated
with the development of resistance to cis-platinum in human ovarian cancer cells, and that …
with the development of resistance to cis-platinum in human ovarian cancer cells, and that …
Acute overexpression of wt p53 facilitates anticancer drug‐induced death of cancer and normal cells
MV Blagosklonny, WS El‐Deiry - International journal of cancer, 1998 - Wiley Online Library
The relationship between chemosensitivity and p53 is currently considered from two
mutually exclusive points of view:(1) wt p53 increases chemosensitivity due to apoptosis and …
mutually exclusive points of view:(1) wt p53 increases chemosensitivity due to apoptosis and …
7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines
HH Xiao, Y Makeyev, J Butler, B Vikram… - Radiation …, 2002 - meridian.allenpress.com
Abstract Xiao, HH, Makeyev, Y., Butler, J., Vikram, B. and Franklin, WA 7-
Hydroxystaurosporine (UCN-01) Preferentially Sensitizes Cells with a Disrupted TP53 to …
Hydroxystaurosporine (UCN-01) Preferentially Sensitizes Cells with a Disrupted TP53 to …
Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation.
G Del Bino, S Bruno, PN Yi, Z Darzynkiewicz - Cell proliferation, 1992 - europepmc.org
We have previously observed that the DNA topoisomerase I inhibitor camptothecin (CAM),
or DNA topoisomerase II inhibitors teniposide (TEN) and amsacrine (m-AMSA) trigger …
or DNA topoisomerase II inhibitors teniposide (TEN) and amsacrine (m-AMSA) trigger …
Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype
LA Parsels, RC Zellars, TL Loney, JD Parsels… - Molecular …, 1997 - ASPET
We have examined the effects of conditionally expressing wild-type p53 activity in HT29
cells on DNA damage and cytotoxicity caused by exposure to fluorodeoxyuridine (FdUrd) …
cells on DNA damage and cytotoxicity caused by exposure to fluorodeoxyuridine (FdUrd) …
Up-Regulation of a Mutant Form of p53 by Doxorubicin in Human Squamous Carcinoma Cells
TT Kwok, CH Mok, L Menton-Brennan - Cancer research, 1994 - AACR
Human squamous carcinoma A431 cells express a high level of epidermal growth factor
(EGF) receptor. The cells carry only a mutated form of the p53 gene, the G→ A mutation at …
(EGF) receptor. The cells carry only a mutated form of the p53 gene, the G→ A mutation at …
The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization
M Chen, AM Hough, TS Lawrence - Cancer chemotherapy and …, 2000 - Springer
Purpose: We compared the cytotoxic and radiosensitizing effects of gemcitabine (2′, 2′-
difluoro-2′-deoxycytidine, dFdCyd), a clinically valuable radiosensitizer, in colon cancer …
difluoro-2′-deoxycytidine, dFdCyd), a clinically valuable radiosensitizer, in colon cancer …