The transient receptor potential Melastatin 4 (TRPM4) channel is a calcium-activated non-
selective cation channel expressed widely. In the heart, using a knock-out mouse model, the …

Transient receptor potential melastatin 4 (TRPM4) cation channels act in cardiomyocytes as
a negative modulator of the L-type Ca 2+ current. Ubiquitous Trpm4 deletion in mice leads to …

Magnesium-sensitive transient receptor potential melastatin (TRPM) ion channels, TRPM6
and TRPM7, are present in several organs, but their roles in the heart remain unclear …

Atrioventricular block (AVB) is a leading cause of sudden cardiac death, and most of AVB
cases are presented as autosomal dominant. The electrocardiogram of AVB patients …

Developmental and epileptic encephalopathies (DEE) are a broad and varied group of
disorders that affect the brain and are characterized by epilepsy and comorbid intellectual …

Objective: A calcium-activated nonselective cation channel (NSCCa) has been recently
described in several cardiac preparations. This channel is over-expressed in models of …

The expression of the channels-enzymes TRPM6 and TRPM7 in the human heart remains
poorly defined, and TRPM6 is generally considered not to be expressed in cardiomyocytes …

In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a
single mutation,'E7K', was identified in its distal N-terminus to cause conduction disorder …

Cardiac channelopathies, mainly Long QT and Brugada syndromes, are genetic disorders
for which genotype/phenotypes relationships remains to be improved. To provide new …

Hypertension is an underlying risk factor for cardiovascular disease. Despite this, its
pathogenesis remains unknown in most cases. Recently, the transient receptor potential …