Background Idebenone is a well-appreciated mitochondrial protectant while the
mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) …

Ischemic stroke is a devastating disease with long-term disability. However, the
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …

Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in
mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular …

Objective Current therapies for ischemia/reperfusion are insufficient because of our poor
understanding of the mechanisms of brain injury after ischemic stroke. As a vital component …

Background The NOD-like receptor family pyrin domain-containing 3 (NLRP3)
inflammasome is an important mediator of neuroinflammatory responses that regulates …

NLRP3 inflammasome is a key mediator in ischemic stroke-induced neuroinflammation and
subsequent brain injury. Our previous study demonstrated the potent activity of Pien-Tze …

The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in cerebral
ischemia. Autophagy may cause microglial inflammatory response or stimulate microglial …

Objective: Minocycline, a tetracycline antibiotic, has shown anti-inflammatory effects in
cerebral ischemia and neurodegenerative disease; however, the molecular mechanisms …

Background & Aims Tetrandrine (Tet) has been reported to have anti-inflammatory effects
and protect from the ischemic strokes. The NLRP3 inflammasome plays a key role in …

Background Mitochondrial autophagy, the elimination of damaged mitochondria through
autophagy, contributes to neuron survival in cerebral ischemia. Long non-coding RNAs …