The role of magnesium sulfate (MgSO4) in fetal neuroprotection

MA Bachnas, MIA Akbar, EG Dachlan… - The Journal of Maternal …, 2021 - Taylor & Francis
Prevention of neurologic disability associated with preterm birth is one of the major
challenges in current perinatal medicine. Magnesium sulfate (MgSO4), the focus of this …

Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta‐analysis and trial sequential analysis

HT Wolf, LD Huusom, TB Henriksen… - … journal of obstetrics …, 2020 - Wiley Online Library
Background Ordinary meta‐analyses indicate that magnesium sulphate (MgSO4) treatment
in women at imminent risk for preterm delivery decreases the offspring's risk of cerebral …

Magnesium sulfate use for fetal neuroprotection

KF Brookfield, A Vinson - Current Opinion in Obstetrics and …, 2019 - journals.lww.com
Magnesium sulfate in some dosage given before very preterm pregnancy delivery is
beneficial for fetal neuroprotection. The exact dose, duration, and timing of administration to …

FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection

A Shennan, N Suff, B Jacobsson… - … of Gynecology & …, 2021 - Wiley Online Library
In women at risk of early preterm imminent birth, from viability to 30 weeks of gestation, use
of MgSO4 for neuroprotection of the fetus is recommended. In pregnancies below 32–34 …

Fetal neuroprotection by magnesium sulfate: from translational research to clinical application

C Chollat, L Sentilhes, S Marret - Frontiers in neurology, 2018 - frontiersin.org
Despite improvements in perinatal care, preterm birth still occurs regularly and the
associated brain injury and adverse neurological outcomes remain a persistent challenge …

Magnesium sulfate and fetal neuroprotection: overview of clinical evidence

C Chollat, S Marret - Neural regeneration research, 2018 - journals.lww.com
Antenatal administration of magnesium sulfate is an important part of the neuroprotective
strategy for preterm infants. Strong evidence from five randomized controlled trials and five …

A systematic review of magnesium sulfate for perinatal neuroprotection: what have we learnt from the past decade?

R Galinsky, JM Dean, I Lingam, NJ Robertson… - Frontiers in …, 2020 - frontiersin.org
There is an important unmet need to improve long term outcomes of encephalopathy for
preterm and term infants. Meta-analyses of large controlled trials suggest that maternal …

Antenatal magnesium sulfate for fetal neuroprotection: a critical appraisal and systematic review of clinical practice guidelines

PM Jayaram, MK Mohan, I Farid… - Journal of perinatal …, 2019 - degruyter.com
Background Magnesium sulfate is an accepted intervention for fetal neuroprotection. There
are some perceived differences in the international recommendations on the use …

Magnesium sulphate given before very‐preterm birth to protect infant brain: the randomised controlled PREMAG trial

S Marret, L Marpeau, V Zupan‐Simunek… - … Journal of Obstetrics …, 2007 - Wiley Online Library
Objective To evaluate whether magnesium sulphate (MgSO4) given to women at risk of very‐
preterm birth would be neuroprotective in preterm newborns and would prevent neonatal …

Magnesium sulphate at 30 to 34 weeks' gestational age: neuroprotection trial (MAGENTA)-study protocol

CA Crowther, PF Middleton, D Wilkinson… - BMC pregnancy and …, 2013 - Springer
Background Magnesium sulphate is currently recommended for neuroprotection of preterm
infants for women at risk of preterm birth at less than 30 weeks' gestation, based on high …