DNA methylation as an important, essential epigenetic modification is critical for the
successful development of mammalian embryos. In recent years, the important role of …

L-ascorbic acid (Vitamin C) can enhance the meiotic maturation and developmental
competence of porcine oocytes, but the underlying molecular mechanism remains obscure …

Aberrant DNA methylation reduces the developmental competence of mammalian somatic
cell nuclear transfer (SCNT) embryos. Thus, hypomethylation-associated drugs are …

Low cloning efficiency limits the wide application of somatic cell nuclear transfer technology.
Apoptosis and incomplete DNA methylation reprogramming of pluripotency genes are …

Incomplete DNA methylation reprogramming in cloned embryos leads to low cloning
efficiency. Our previous studies showed that the epigenetic modification agents 5-aza-2' …

Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning
efficiency. Melatonin has been proven to improve the development of cloned embryos …

Objective Investigated the effect and mechanism of ascorbic acid on the development of
porcine embryos produced by somatic cell nuclear transfer (SCNT). Methods Porcine …

Apoptosis and incomplete DNA methylation reprogramming in cloned embryos reduce
cloning efficiency. 5-aza-2′-deoxycytidine (5-aza-dC) is proven to regulate apoptosis and …

The methylation pathway, which consists of two metabolic cycles of nutrients, ie, the
methionine and folate cycles, generates S‐adenosylmethionine, the methyl donor for the …

Aberrant epigenetic reprogramming is known to be a major cause of inefficient somatic cell
nuclear transfer (SCNT) in pigs, and use of epigenetic modification agents, such as DNA …