In an attempt to determine the incidence and clinical relevance of mdr1 gene expression in
acute myeloid leukemia (AML), we examined 126 specimens obtained from adult patients …

To prospectively assess the role of MDR1 gene expression in patients with de novo acute
myeloid leukemia (AML), levels of MDR1 RNA in blast cells were determined at diagnosis …

Introduction: The multidrug resistance protein 1 (MDR1) has the capacity to extrude
chemotherapeutics and has been implicated in treatment failure in acute myeloid leukemia …

The expression of the MDR1 gene was studied by Northern blot analysis in leukaemic cell
specimens obtained from 74 patients with acute myelogenous leukaemia (AML). No …

The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia
(AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor …

MDR1 gene expression was examined in acute leukemia cells from 75 Japanese patients at
diagnosis (50 with acute myeloblastic leukemia [AML]: 10 M1, 18 M2, 5 M3, 8 M4, 9 M5; 25 …

Resistance to cytotoxic agents may be encountered during the treatment of acute
myeloblastic leukaemia (AML). P-glycoprotein encoded by the MDR-1 gene has been …

In order to further define the role of the MDR1 gene in acute myeloid leukemia (AML), we
determined the association between the presence of P-glycoprotein on leukemic cells and …

The expression of P-glycoprotein (P-gp), encoded by the MDR 1 gene, is an independent
adverse prognostic factor for response and survival in de novo acute myeloid leukemia …

By using a quantitative RNA-RNA solution hybridisation method, the average number of
mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells …