Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …

A balance between pro-and anti-inflammatory mechanisms at mucosal interfaces, which are
sites of constitutive exposure to microbes and non-microbial foreign substances, allows for …

Little is known about how the microbiota regulates T cell proliferation and whether
spontaneous T cell proliferation is involved in the pathogenesis of inflammatory bowel …

Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-
dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα+ innate …

Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against
pathogens and controls intestinal microbiota composition. However, mechanisms regulating …

Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting
inflammatory responses to nonself antigens. Within the intestine, pTregs are located …

The intestinal microbiota has a critical role in immune system and metabolic homeostasis,
but it must be tolerated by the host to avoid inflammatory responses that can damage the …

Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in
the spleen, they fail to induce CD4+ T cell proliferation in the gut. The signals regulating …

Background Well-balanced interactions between gut microbiota and the immune system are
essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel …

Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of immune
homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate …