In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing
the same and the recombinant adenovirus vectors produced thereby, are provided. In the …

Site-specific recombinase based methods for making a recombinant adenoviral genome, as
well as kits for practic ing the same and the recombinant adenovirus vectors pro duced …

US20030096787A1 - Defective adenovirus vectors and use thereof in gene therapy - Google
Patents US20030096787A1 - Defective adenovirus vectors and use thereof in gene therapy …

the present invention relates generally to the fields of cell culture and virus production. More
particularly, it concerns improved methods for the culturing of mammalian cells, infection of …

(57) ABSTRACT A method for producing in vivo packaged recombinant adenovirus vectors
is provided. The recombinant Ad vectors do not contain any Adenovirus genes and are …

The present invention is directed to novel replication-defi cient adenoviral vectors
characterized in that they harbor at least two lethal early region gene deletions (E1 and E4) …

Presented are ways to address the problem of replication competent adenovirus in
adenoviral production for use with, for example, gene therapy. Packaging cells having no …

The invention relates to methods and means for the produc tion of adenoviral vectors on
complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) …

The present invention relates to recombinant adenoviruses and vectors thereof. In particular,
the adenoviruses are novel simian adenoviruses having a low seroprevalence and high …

(57) ABSTRACT A novel adenovirus E1/E4 expressing packaging cell line is provided,
which permits the generation of recombinant adenoviruses deleted in both gene regions …