[HTML][HTML] Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in …

EK Mohamed, DM Hafez - BMC Complementary Medicine and Therapies, 2023 - Springer
Background Hepatic encephalopathy (HE) is a consequence of chronic or acute liver
diseases. This study evaluates the combined effect of gallic acid (GA), and metformin (Met) …

Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural …

NA Afifi, A Ramadan, EY Erian, AA Sedik… - Canadian journal of …, 2021 - cdnsciencepub.com
Hepatic encephalopathy depicts the cluster of neurological alterations that occur during
acute or chronic hepatic injury. Hyperammonemia, inflammatory injury, and oxidative stress …

Cinnamaldehyde/lactulose combination therapy alleviates thioacetamide-induced hepatic encephalopathy via targeting P2X7R-mediated NLRP3 inflammasome …

G Al Shaima, NA Abd Elrazik - Life Sciences, 2024 - Elsevier
Aims Cinnamaldehyde (CA), the main active constituent of cinnamon oil, is reported to have
neuroprotective effects. However, the potential benefits of CA for brain protection in hepatic …

Thioacetamide-induced acute hepatic encephalopathy: central vs peripheral effect of Allicin

DO Saleh, DF Mansour, AM Fayez - Metabolic Brain Disease, 2021 - Springer
Hepatic encephalopathy (HE) is a debilitating and life-threatening disease. Results from
acute or chronic liver failure and is characterized by abnormal cerebral and neurological …

Protective effects of Tinospora cordifolia miers extract against hepatic and neurobehavioral deficits in thioacetamide-induced hepatic encephalopathy in rats via …

SA Ali, AK Datusalia - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Tinospora cordifolia (TC) a potential medicinal herb, has
been ethnobotanically used as an eco-friendly supplement to manage various diseases …

Naringenin mitigates thioacetamide-induced hepatic encephalopathy in rats: Targeting the JNK/Bax/caspase-8 apoptotic pathway

SM Eraky, DH El-Kashef, M El-Sherbiny… - Food & Function, 2023 - pubs.rsc.org
Hepatic encephalopathy (HE) is a serious neurological disorder which is related to liver
dysfunction. HE was induced by thioacetamide (TAA) injection (350 mg kg− 1, ip) for 3 …

[HTML][HTML] Neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and …

AA Sedik, DT Hussein, K Fathy, NA Mowaad - Scientific Reports, 2024 - nature.com
Acute liver injury, there is a risky neurological condition known as hepatic encephalopathy
(HE). Herbacetin is a glycosylated flavonoid with many pharmacological characteristics. The …

Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/IL-17/IL-23 …

RS Abdelrahman, GS El-Tanbouly - Toxicology and Applied Pharmacology, 2022 - Elsevier
Protocatechuic acid (PCA), a natural phenolic acid, is known for antioxidant, anti-
inflammatory, anti-apoptotic, and anti-fibrotic activities. However, the protective mechanisms …

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling …

HA Ogaly, RF Abdel-Rahman, MAE Mohamed… - Food & Function, 2022 - pubs.rsc.org
In the present study, we aimed to delineate the neuroprotective potential of thymol (THY)
against neurotoxicity and cognitive deterioration induced by thioacetamide (TAA) in an …

[HTML][HTML] Neuromodulatory role of L-arginine: nitric oxide precursor against thioacetamide-induced-hepatic encephalopathy in rats via downregulation of NF-κB …

AA Sedik, A Hassan, DO Saleh - Environmental Science and Pollution …, 2023 - Springer
The aim of the present study was to investigate the impact of arginine (ARG), a nitric oxide
(NO) precursor, on thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats by …