Abstract Background and Aim: Increased production of reactive oxygen species and nitric
oxide and activation of nuclear factor κ B are implicated in the pathogenesis of various liver …

Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon
tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models …

Abstract Background The cGAS-STING pathway is an important component of the innate
immune system and plays significant role in acetaminophen-induced liver injury (AILI) …

Liver cirrhosis is a silent disease in humans and is experimentally induced by many drugs
and toxins as thioacetamide (TAA) in particular, which is the typical model for experimental …

The antioxidant effect of caffeine, associated with its ability to upregulate the nuclear factor-
E2-related factor-2 (Nrf2)-signaling pathway, was explored as a possible mechanism for the …

OBJECTIVE: Non-alcoholic fatty liver disorders (NAFLD), particularly non-alcoholic
steatohepatitis (NASH), have emerged as a leading cause of liver transplantation and …

Hyperammonemia is a serious metabolic disorder associating with hepatic encephalopathy
(HE) which occurs secondary to several forms of liver injury ranging from simple acute liver …

Background Fluoxetine-induced liver damage is a cause of chronic liver disease. In the
present study the hepatoprotective effects of gallic acid against fluoxetine-induced liver …

Background: Hepatic encephalopathy (HE) is a major health concern worldwide with a
significant morbidity and mortality in addition to the economic burden. Oxidative stress …

Cognitive impairments induced by severe acute pancreatitis (SAP) are severe
complications, for which there are a lack of effective pharmacological treatment strategies …