Icariin stimulates angiogenesis by activating the MEK/ERK-and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells

BH Chung, JD Kim, CK Kim, JH Kim, MH Won… - Biochemical and …, 2008 - Elsevier
We investigated the molecular effect and signal pathway of icariin, a major flavonoid of
Epimedium koreanum Nakai, on angiogenesis. Icariin stimulated in vitro endothelial cell …

Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro

HB Xu, ZQ Huang - Vascular Pharmacology, 2007 - Elsevier
Icariin, a flavonoid isolated from Epimedii herba, is considered to be the major therapeutical
constituent of E. herba. The aim of this study was to investigate the possible protective …

[HTML][HTML] Kaempferol inhibits angiogenesis by suppressing HIF-1α and VEGFR2 activation via ERK/p38 MAPK and PI3K/Akt/mTOR signaling pathways in endothelial …

GD Kim - Preventive Nutrition and Food Science, 2017 - ncbi.nlm.nih.gov
Kaempferol has been shown to inhibit vascular formation in endothelial cells. However, the
underlying mechanisms are not fully understood. In the present study, we evaluated whether …

Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro.

T Hisa, Y Kimura, K Takada, F Suzuki… - Anticancer …, 1998 - europepmc.org
Angiogenesis is critical for tumor growth and inflammation. Shiunko is a Chinese herbal
ointment used for the treatment of burns in Japan. Its main ingredient is the root of …

[HTML][HTML] Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular …

HN Chang, ST Huang, YC Yeh, HS Wang… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Indigo naturalis has been used to treat inflammatory
diseases and dermatosis, including psoriasis, since thousands of years in China. It has been …

The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo

HW Lam, HC Lin, SC Lao, JL Gao… - Journal of cellular …, 2008 - Wiley Online Library
Angiogenesis plays an important role in a wide range of physiological processes such as
wound healing and fetal development. Many diseases are associated with imbalances in …

Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway

SM Won, YH Park, HJ Kim, KM Park… - Experimental & molecular …, 2006 - nature.com
Catechins, components of green tea, reduce the incidence of cardiovascular diseases such
as atherosclerosis. Angiotensin II (Ang II) is highly implicated in the proliferation of vascular …

Anti‐angiogenic potential of scopoletin is associated with the inhibition of ERK1/2 activation

R Pan, Y Dai, J Yang, Y Li, X Yao… - Drug Development …, 2009 - Wiley Online Library
Angiogenesis plays an important role in many diseases, such as cancer, rheumatoid
arthritis, and diabetic retinopathy. Specific inhibitors of angiogenesis are therefore expected …

[HTML][HTML] Kaempferol, a major flavonoid in ginkgo folium, potentiates angiogenic functions in cultured endothelial cells by binding to vascular endothelial growth factor

WH Hu, HY Wang, YT Xia, DK Dai, QP Xiong… - Frontiers in …, 2020 - frontiersin.org
Kaempferol is a major flavonoid in Ginkgo Folium and other edible plants, which is being
proposed here to have roles in angiogenesis. Angiogenesis is important in both …

[HTML][HTML] Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor

S Shankar, Q Chen, RK Srivastava - Journal of molecular signaling, 2008 - Springer
Background We have recently shown that epigallocatechin-3-gallate (EGCG), a
polyphenolic compound from green tea, inhibits angiogenesis. However, the molecular …