Effective diphtheria, tetanus toxoids, whole-cell pertussis (DTwP) vaccines became
available in the 1930s, and they were put into routine use in the United States in the 1940s …

The last 25 years have been tumultuous in re-gard to immunization for the prevention of
pertussis. 1 Although effective vaccines became available 50 years ago, exaggerated fears …

States and other countries in which infants and children are universally immunized. 1–3
Presently, this “resurgence” of pertussis is presented with alarm in frequent newspaper …

Pertussis is an epidemic disease caused by Bordetella pertussis and also to a lesser extent
by Bordetella parapertussis. Classical illness lasts 4–8 weeks and is characterized by …

Background: The epidemiology of pertussis is changing, with a clear increase in the number
of cases diagnosed in adolescents and adults. This development has spurred studies and …

Background. Despite the dramatic pertussis decrease since the licensure of whole-cell
pertussis (diphtheria-tetanus toxoids-pertussis [DTP]) vaccines in the middle 1940s …

The article by Warfel et al. in PNAS is noteworthy (1) because it shows that in nonhuman
primate pertussis challenge models, acellular pertussis vaccines protect against disease but …

The significant burden of disease due to pertussis, which predominantly affects newborns
during their first few months of life, was substantially decreased following the introduction of …

Objective. To compare the safety and immunogenicity of 12 different acellular pertussis
vaccines combined with diphtheria and tetanus toxoids (DTaP) with one licensed diphtheria …

Concerns about the safety of whole-cell pertussis vaccines prompted development of
acellular vaccines that are less likely to provoke adverse events because they contain …