Background—We studied whether aspirin resistance, defined as failure of suppression of
thromboxane generation, increases the risk of cardiovascular events in a high-risk …

Background—Incomplete inhibition of platelet thromboxane generation, as measured by
elevated urinary 11-dehydro thromboxane B2 concentrations, has been associated with an …

Study Objective. To determine whether urinary 11‐dehydrothromboxane B2 (d‐TXB2) is a
marker of aspirin resistance and define the relationship between aspirin dosage and …

Resistance to inhibition of platelet function by aspirin may contribute to future myocardial
infarction and stroke. Adverse cardiovascular outcomes have been associated with aspirin …

The capacity of platelets to generate thromboxane A2, reflected by measurement of serum
thromboxane B2 (TxB2), greatly exceeds the systemic production of thromboxane in vivo …

We studied the time-and dose-dependence of the inhibitory effect of oral aspirin on platelet
production of thromboxane (TX) B 2 in response to endogenously formed thrombin, by …

Objective: This study was conducted to assess the thromboxane (TX) dependence of
biochemical and functional indexes used to monitor the effect of low-dose aspirin …

Background—Thrombotic events still occur in aspirin-treated patients with coronary artery
disease. Methods and Results—To better understand aspirin “resistance,” serum …

Aspirin resistance refers to less than expected suppression of thromboxane A2 production
by aspirin and has been reported to be independently associated with an increased risk of …

Objectives: Although the concept of aspirin resistance is extensively reported in medical
literature, its precise mechanisms and clinical outcomes are largely unknown. In this study …