The conversion of centrioles to centrosomes: essential coupling of duplication with segregation

WJ Wang, RK Soni, K Uryu, MF Bryan Tsou - Journal of Cell Biology, 2011 - rupress.org
Centrioles are self-reproducing organelles that form the core structure of centrosomes or
microtubule-organizing centers (MTOCs). However, whether duplication and MTOC …

[HTML][HTML] Centrin-2 is required for centriole duplication in mammalian cells

JL Salisbury, KM Suino, R Busby, M Springett - Current Biology, 2002 - cell.com
Background: Centrosomes are the favored microtubule-organizing framework of eukaryotic
cells. Centrosomes contain a pair of centrioles that normally duplicate once during the cell …

[HTML][HTML] CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion

ES Atorino, S Hata, C Funaya, A Neuner… - Nature …, 2020 - nature.com
Centrosomes are essential organelles with functions in microtubule organization that
duplicate once per cell cycle. The first step of centrosome duplication is the daughter …

Centriole assembly at a glance

P Gönczy, GN Hatzopoulos - Journal of cell science, 2019 - journals.biologists.com
The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial
symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling …

The centriole duplication cycle

EN Fırat-Karalar, T Stearns - … Transactions of the Royal …, 2014 - royalsocietypublishing.org
Centrosomes are the main microtubule-organizing centre of animal cells and are important
for many critical cellular and developmental processes from cell polarization to cell division …

Conserved molecular interactions in centriole-to-centrosome conversion

J Fu, Z Lipinszki, H Rangone, M Min, C Mykura… - Nature cell …, 2016 - nature.com
Centrioles are required to assemble centrosomes for cell division and cilia for motility and
signalling. New centrioles assemble perpendicularly to pre-existing ones in G1–S and …

[HTML][HTML] Ab ovo or de novo? Mechanisms of centriole duplication

J Loncarek, A Khodjakov - Molecules and cells, 2009 - Elsevier
The centrosome, an organelle comprising centrioles and associated pericentriolar material,
is the major microtubule organizing center in animal cells. For the cell to form a bipolar …

[PDF][PDF] Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion

D Izquierdo, WJ Wang, K Uryu, MFB Tsou - Cell reports, 2014 - cell.com
Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis,
concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby …

[HTML][HTML] Centrioles: active players or passengers during mitosis?

A Debec, W Sullivan, M Bettencourt-Dias - Cellular and molecular life …, 2010 - Springer
Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes.
Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their …

Centrosome maturation–in tune with the cell cycle

J Blanco-Ameijeiras… - Journal of Cell …, 2022 - journals.biologists.com
Centrosomes are the main microtubule-organizing centres, playing essential roles in the
organization of the cytoskeleton during interphase, and in the mitotic spindle, which controls …