Clustering and dynamics of crowded proteins near membranes and their influence on membrane bending
Atomistic molecular dynamics simulations of concentrated protein solutions in the presence
of a phospholipid bilayer are presented to gain insights into the dynamics and interactions at …
of a phospholipid bilayer are presented to gain insights into the dynamics and interactions at …
Membrane compartmentalization reducing the mobility of lipids and proteins within a model plasma membrane
The cytoskeleton underlying cell membranes may influence the dynamic organization of
proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins …
proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins …
Thermodynamics and kinetics of aggregation of flexible peripheral membrane proteins
Biomembrane remodeling is essential for cellular trafficking, with membrane-binding
peripheral proteins playing a key role in it. Significant membrane remodeling as in endo-and …
peripheral proteins playing a key role in it. Significant membrane remodeling as in endo-and …
[HTML][HTML] Aggregation of model membrane proteins, modulated by hydrophobic mismatch, membrane curvature, and protein class
DL Parton, JW Klingelhoefer, MSP Sansom - Biophysical journal, 2011 - cell.com
Aggregation of transmembrane proteins is important for many biological processes, such as
protein sorting and cell signaling, and also for in vitro processes such as two-dimensional …
protein sorting and cell signaling, and also for in vitro processes such as two-dimensional …
[HTML][HTML] Simulation studies of protein-induced bilayer deformations, and lipid-induced protein tilting, on a mesoscopic model for lipid bilayers with embedded proteins
M Venturoli, B Smit, MM Sperotto - Biophysical journal, 2005 - cell.com
Biological membranes are complex and highly cooperative structures. To relate
biomembrane structure to their biological function it is often necessary to consider simpler …
biomembrane structure to their biological function it is often necessary to consider simpler …
[HTML][HTML] Molecular simulations of lipid-mediated protein-protein interactions
FJM De Meyer, M Venturoli, B Smit - Biophysical journal, 2008 - cell.com
Recent experimental results revealed that lipid-mediated interactions due to hydrophobic
forces may be important in determining the protein topology after insertion in the membrane …
forces may be important in determining the protein topology after insertion in the membrane …
Crowding effects of membrane proteins
HX Zhou - The journal of physical chemistry B, 2009 - ACS Publications
In cell membranes, membrane proteins occupy∼ 30% of the total surface area. Crowding
effects similar to those in the solution phase are thus to be expected. In addition, there are …
effects similar to those in the solution phase are thus to be expected. In addition, there are …
[HTML][HTML] Molecular dynamics simulations of membrane proteins and their interactions: from nanoscale to mesoscale
Highlights•Simulations provide a computational tool to probe membrane structure and
dynamics.•Simulations can successfully predict lipid binding sites on membrane …
dynamics.•Simulations can successfully predict lipid binding sites on membrane …
Setting up and running molecular dynamics simulations of membrane proteins
C Kandt, WL Ash, DP Tieleman - Methods, 2007 - Elsevier
Molecular dynamics simulations have become a popular and powerful technique to study
lipids and membrane proteins. We present some general questions and issues that should …
lipids and membrane proteins. We present some general questions and issues that should …
Atomistic and coarse-grained simulations of membrane proteins: a practical guide
D Jefferies, S Khalid - Methods, 2021 - Elsevier
Membrane proteins are amphipathic macromolecules whose exposed hydrophobic surfaces
promote interactions with lipid membranes. Membrane proteins are remarkably diverse in …
promote interactions with lipid membranes. Membrane proteins are remarkably diverse in …