Atomistic molecular dynamics simulations of concentrated protein solutions in the presence
of a phospholipid bilayer are presented to gain insights into the dynamics and interactions at …

The cytoskeleton underlying cell membranes may influence the dynamic organization of
proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins …

Biomembrane remodeling is essential for cellular trafficking, with membrane-binding
peripheral proteins playing a key role in it. Significant membrane remodeling as in endo-and …

Aggregation of transmembrane proteins is important for many biological processes, such as
protein sorting and cell signaling, and also for in vitro processes such as two-dimensional …

Biological membranes are complex and highly cooperative structures. To relate
biomembrane structure to their biological function it is often necessary to consider simpler …

Recent experimental results revealed that lipid-mediated interactions due to hydrophobic
forces may be important in determining the protein topology after insertion in the membrane …

In cell membranes, membrane proteins occupy∼ 30% of the total surface area. Crowding
effects similar to those in the solution phase are thus to be expected. In addition, there are …

Highlights•Simulations provide a computational tool to probe membrane structure and
dynamics.•Simulations can successfully predict lipid binding sites on membrane …

Molecular dynamics simulations have become a popular and powerful technique to study
lipids and membrane proteins. We present some general questions and issues that should …

Membrane proteins are amphipathic macromolecules whose exposed hydrophobic surfaces
promote interactions with lipid membranes. Membrane proteins are remarkably diverse in …