Highlights•Chemical synthesis provided access to O-linked and S-linked oligosialic
acids.•Oxazolidinone-protected sialyl donors enable α-selective sialylation.•Enzymatic …

Sialic acids on the non-reducing terminus of sialylgylcans are abundantly expressed on the
surface of mammalian cells. They play vital roles in cell-cell interactions and during infection …

Conspectus Sialic acids are fascinating negatively charged nine-carbon monosaccharides.
Sialic acid-containing glycans and glycoconjugates are structurally diverse, functionally …

The biological relevance of sialic acid-containing glycans (sialo-glycans) to various
interactions at the cell surface has increased the demand for the supply of structurally …

Sialic acid is an important component of cell surface glycans, which are responsible for
many vital body functions and should therefore be thoroughly studied to understand their …

Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Sialic acids usually occur as glycosides of functional glycoconjugates such as
glycoprooteins and glycolips, that are involved in a wide range of biological phenomena, for …

Sialic acid‐containing glycans play important roles in biology, but their synthesis by
standard chemical approaches is challenging. Enzymatic assembly is generally a better …

Chemical construction of a α-glycoside of sialic acid is a demanding subject due to the
structural disadvantages of sialic acid: the carboxylate group at C1, the deoxy moiety …

Sialic acid-containing glycans play a major role in cell-surface interactions with external
partners such as cells and viruses. Straightforward access to sialosides is required in order …