The occurrence of seizures at specific times of the day has been consistently observed for
centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that …

The circadian pattern of seizures in people with epilepsy was first described two millennia
ago. However, these phenomena have not received enough scientific attention, possibly …

Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and
epilepsy. Comprehending how these interact with each other may help to advance our …

Epilepsy is a neurological disease characterized by spontaneous, unprovoked seizures.
Various insults render the brain hyperexcitable and susceptible to seizure. Despite there …

The cyclical organization of seizures in epilepsy has been described since antiquity.
However, historical explanations for seizure cycles—based on celestial, hormonal, and …

Personalized medicine requires that treatments adapt to not only the patient but also
changing factors within each individual. Although epilepsy is a dynamic disorder …

Seizure patterns observed in patients with epilepsy suggest that circadian rhythms and
sleep/wake mechanisms play some role in the disease. This review addresses key topics in …

Extensive study has demonstrated that epilepsy occurs with greater frequency at certain
times in the 24‐h cycle. Although these findings implicate an overlap between the circadian …

Circadian rhythms are endogenously-mediated 24 h cycles of behavioral or physiological
activity. The interactions among the mammalian circadian clock, acute seizures, and chronic …

Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the
brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal …