PURPOSE: To quantify cephalocaudal gradient of lung inflation in acute lung injury in a dog
model in prone versus supine position. MATERIALS AND METHODS: Experiments were …

Rationale: It remains unclear how prone positioning improves survival in acute respiratory
distress syndrome. Using serial computed tomography (CT), we previously reported that …

Background Prone ventilation redistributes lung inflation along the gravitational axis;
however, localized, nongravitational effects of body position are less well characterized. The …

Rationale: Mechanical ventilation in the prone position may be an effective means of
recruiting nonaerated alveolar units and minimizing ventilation-induced lung injury …

Background There is debate whether pressure transmission within the lungs and alveolar
collapse follow a hydrostatic pattern or the compression exerted by the weight of the heart …

The effect of body position on regional pulmonary blood flow (rPBF) and lung water
concentration (rLWC) was studied before and after canine oleic acid (OA)-induced acute …

OBJECTIVES: It is not known how lung injury progression during mechanical ventilation
modifies pulmonary responses to prone positioning. We compared the effects of prone …

New Findings What is the central question of this study? How does the interaction between
posture and gravity affect the stresses on the lung, particularly in highly inflated …

Objective: Severe posttraumatic lung injury is characterized by impairment of gas exchange
and pulmonary densities. The influence of intermittent prone positioning on pulmonary gas …

Background: We previously demonstrated a markedly dependent distribution of ventilator-
induced lung injury in oleic acid-injured supine animals ventilated with large tidal volumes …