Once a fatal disease of childhood, more than 95% of patients born today with sickle cell
disease (SCD) in developed countries are expected to survive into adulthood, largely …

Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

Sickle cell disease (SCD) is a life-threatening genetic disorder characterized by chronic
hemolytic anemia, vascular injury and multiorgan dysfunctions. Over the last few decades …

Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …

Sickle cell disease (SCD), one of the most common monogenetic diseases in the world, is
associated with multisystemic complications that begin in childhood. Most of the babies …

Early identification of infants with sickle cell disease (SCD) by newborn screening, now
universal in all 50 states in the US, has improved survival, mainly by preventing …

Children with sickle cell disease may present to doctors anywhere in the world. In developed
countries, neonatal screening allows early identification and management of the disease …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …

Introduction: The perception of an asymptomatic sickle cell disease (SCD) state is a
misnomer. Children without overt symptoms, likely have subclinical disease beginning in …

Sickle cell disease (SCD) is one of the commonest inherited diseases in the UK, affecting
approximately 1 in 4000 live births every year. For the majority of patients, the mainstays of …