The molecular characterization and clinical management of multiple myeloma in the post-genome era
Y Zhou, B Barlogie, JD Shaughnessy - Leukemia, 2009 - nature.com
Cancer-causing mutations disrupt coordinated, precise programs of gene expression that
govern cell growth and differentiation. Microarray-based gene-expression profiling (GEP) is …
govern cell growth and differentiation. Microarray-based gene-expression profiling (GEP) is …
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
T Hideshima, C Mitsiades, G Tonon… - Nature Reviews …, 2007 - nature.com
Multiple myeloma is a plasma cell malignancy characterized by complex heterogeneous
cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma …
cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma …
Cutting edge genomics reveal new insights into tumour development, disease progression and therapeutic impacts in multiple myeloma
Multiple Myeloma (MM) is a haematological malignancy characterised by the clonal
expansion of plasma cells (PC s) within the bone marrow. Despite advances in therapy, MM …
expansion of plasma cells (PC s) within the bone marrow. Despite advances in therapy, MM …
Genomic heterogeneity in multiple myeloma
R Szalat, NC Munshi - Current opinion in genetics & development, 2015 - Elsevier
Multiple myeloma (MM) is an incurable malignancy in majority of patients characterized by
clonal proliferation of plasma cells. To date, treatment is established based on general …
clonal proliferation of plasma cells. To date, treatment is established based on general …
Genomics in multiple myeloma
NC Munshi, H Avet-Loiseau - Clinical Cancer Research, 2011 - AACR
Multiple myeloma (MM) is a complex disease that is driven by numerous genetic and
epigenetic alterations. Comprehensive oncogenomic analysis indicates the presence of …
epigenetic alterations. Comprehensive oncogenomic analysis indicates the presence of …
The epigenome in multiple myeloma: impact on tumor cell plasticity and drug response
E De Smedt, H Lui, K Maes, K De Veirman… - Frontiers in …, 2018 - frontiersin.org
Multiple myeloma (MM) is a clonal plasma cell malignancy that develops primarily in the
bone marrow (BM), where reciprocal interactions with the BM niche foster MM cell survival …
bone marrow (BM), where reciprocal interactions with the BM niche foster MM cell survival …
Genomic basis of multiple myeloma subtypes from the MMRF CoMMpass study
S Skerget, D Penaherrera, A Chari, S Jagannath… - Medrxiv, 2021 - medrxiv.org
Multiple myeloma is a treatable, but currently incurable, hematological malignancy of
plasma cells characterized by diverse and complex tumor genetics for which precision …
plasma cells characterized by diverse and complex tumor genetics for which precision …
The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies
Multiple myeloma (MM) is a hematologic malignancy that is considered mostly incurable in
large part due to the inability of standard of care therapies to overcome refractory disease …
large part due to the inability of standard of care therapies to overcome refractory disease …
Genetic analysis of multiple myeloma identifies cytogenetic alterations implicated in disease complexity and progression
C Li, EB Wendlandt, B Darbro, H Xu, GS Thomas… - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma (MM) is the second most common hematological
neoplasia with a high incidence in elderly populations. The disease is characterized by a …
neoplasia with a high incidence in elderly populations. The disease is characterized by a …
Genome-wide somatic alterations in multiple myeloma reveal a superior outcome group
PURPOSE Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations.
The overall goal of this study was to describe the genomic landscape of myeloma using …
The overall goal of this study was to describe the genomic landscape of myeloma using …