Actinobacteria encode a wealth of natural product biosynthetic gene clusters, whose
systematic study is complicated by numerous repetitive motifs. By combining several metrics …

The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …

Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Covering: 2000 to 2016 The labor-intensive process of microbial natural product discovery is
contingent upon identifying discrete secondary metabolites of interest within complex …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …