The c-fos proto-oncogene mRNA is extremely labile and is rapidly degraded within minutes
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …

The c-fos proto-oncogene transcript is one of the most labile mammalian mRNAs known.
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …

Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene
expression. Experiments were performed to investigate the cellular mechanisms responsible …

The mechanisms by which c-fos mRNA is targeted for decay have been examined. Rapid
removal of the poly (A) tail occurs before the transcribed portion of the c-fos message is …

The protein-coding region of the c-fos proto-oncogene transcript contains elements that
direct the rapid deadenylation and decay of this mRNA in mammalian cells. The function of …

The fos proto-oncogene is rapidly and transiently expressed in resting cells exposed to
growth stimulation. This gene is down-regulated at least at two levels: tran-scriptional …

AU-sequence motifs present in the 3'untranslated region (UTR) of many rapidly inducible
messenger RNAs have been proposed to mediate their selective degradation. We have …

Rapid decay of the c-fos transcript plays a critical role in controlling transforming potential of
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only
by transcriptional activation but also at the level of turnover of the gene product. Here we …

The instability of oncogenic mRNA such as c-fos mRNA is controlled in cis by sequences
present in both the coding and the 3'untranslated regions (3'UTR). The latter contains AU …